High susceptibility of human dendritic cells to invasion by the intracellular pathogens Brucella suis, Brucella abortus, and Brucella melitensis

被引：68

作者：

Billard, E

Cazevieille, C

Dornand, J

Gross, A

机构：

[1] Univ Montpellier 2, INSERM, U431, F-34095 Montpellier, France

[2] IURC, CRIC, F-34093 Montpellier, France

来源：

INFECTION AND IMMUNITY | 2005年 / 73卷 / 12期

关键词：

D O I：

10.1128/IAI.73.12.8418-8424.2005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Bacteria from the Brucella genus are able to survive and proliferate within macrophages. Because they are phylogenetically closely related to macrophages, myeloid dendritic cells (DCs) constitute potential targets for Brucella bacteria. Here we report that DCs display a great susceptibility to Brucella infection. Therefore, DCs might serve as a reservoir and be important for the development of Brucella bacteria within their host.

引用

收藏

页码：8418 / 8424

页数：7

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