A surprisingly mild and versatile method for palladium-catalyzed Suzuki cross-couplings of aryl chlorides in the presence of a triarylphosphine

被引：151

作者：

Liu, SY ^{[1
]}

Choi, MJ ^{[1
]}

Fu, GC ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

CHEMICAL COMMUNICATIONS | 2001年 / 23期

关键词：

D O I：

10.1039/b107888g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the presence of new air-stable triarylphosphine 2, palladium-catalyzed Suzuki reactions of a wide array of aryl chlorides can be accomplished in uniformly good yield, including couplings of very sterically demanding and electronically deactivated substrates; activated aryl chlorides can be coupled at room temperature. In terms of scope and mildness, Pd-2 compares well with other catalyst systems that have been described for Suzuki reactions of aryl chlorides, thereby establishing that triarylphosphines should be regarded as fertile ground for future ligand-design efforts for palladium-catalyzed couplings of aryl chlorides.

引用

页码：2408 / 2409

页数：2

共 24 条

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