Synthesis of 4-substituted phenylalanines by cross-coupling reactions: Extension of the methodology to aryl chlorides

被引：66

作者：

Firooznia, F ^{[1
]}

Gude, C ^{[1
]}

Chan, K ^{[1
]}

Satoh, Y ^{[1
]}

机构：

[1] Novartis Pharmaceut Corp, Metab & Cardiovasc Dis Res, Summit, NJ 07901 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 23期

关键词：

D O I：

10.1016/S0040-4039(98)00749-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Boc-derivative of (4-pinacolylborono)phenylalanine ethyl eater (6) or the corresponding boronic acid 8 undergo Suzuki-Miyaura coupling reactions with aromatic chlorides in the presence of catalytic amounts of PdCl2(PCy3)(2) or NiCl2(dppf), respectively, to produce 4-substituted phenylalanine derivatives. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：3985 / 3988

页数：4

共 11 条

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