Regulation of tissue β-adrenergic, glucocorticoid and androgen receptors induced by repeated exposure to growth promoters in male veal calves

被引：23

作者：

Odore, Rosangela ^{[1
]}

Badino, Paola ^{[1
]}

Barbero, Raffaella ^{[1
]}

Cuniberti, Barbara ^{[1
]}

Pagliasso, Susanna ^{[1
]}

Girardi, Carlo ^{[1
]}

Re, Giovanni ^{[1
]}

机构：

[1] Univ Turin, Dept Anim Pathol, Div Pharmacol & Toxicol, I-10095 Grugliasco, TO, Italy

来源：

RESEARCH IN VETERINARY SCIENCE | 2007年 / 83卷 / 02期

关键词：

calves; clenbuterol; dexamethasone; estradiol; growth promoters; receptors;

D O I：

10.1016/j.rvsc.2006.12.011

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Biochemical modifications induced by a combination of anabolic compounds in target organs of male veal calves have been evaluated. Six male Friesian crossbred calves were treated with of 17 beta-estradiol, dexamethasone sodium phosphate and clenbuterol or served as controls. P-Adrenoceptors (beta-ARs) were measured in myocardium, lung, spleen, cerebral cortex, hippocampus, thalamus, hypothalamus, and hypophysis, glucocorticoid receptors (GRs) in the spleen and androgen receptors (AnRs) in the testis, by binding assay. A significant decrease in beta-ARs was observed in all tissue samples from treated animals. In the spleen the two GR subtypes found, low (LA) and high (HA) affinity GRs, were down-regulated by the treatment. A significant (P < 0.05) decrease of testis weight and a significant (P < 0.05) up-regulation of AnRs was also observed. Our data demonstrate that long-term treatment with anabolic compounds markedly affects receptor concentrations in target organs of male veal calves. Thus, studies investigating biological assays as screening methods to detect such compounds should be encouraged. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：227 / 233

页数：7

共 32 条

[21]

PRESTON RL, 1995, J ANIM SCI, V73, P1038

[22] Effects of clenbuterol as a repartitioning agent on beta-adrenoceptor concentrations in heart, bronchi and brain of veal calves [J].

Re, G ;

Badino, P ;

Novelli, A ;

Girardi, C .

VETERINARY JOURNAL, 1997, 153 (01) :63-70

[23]

RE G, 1995, AM J VET RES, V56, P1493

[24]

RE G, 1993, AM J VET RES, V54, P438

[25] Effects of mepartricin on estradiol and testosterone serum levels and on prostatic estrogen, androgen and adrenergic receptor concentrations in adult rats [J].

Re, G ;

Badino, P ;

Odore, R ;

Vigo, D ;

Bonabello, A ;

Rabino, S ;

Capello, F ;

Bruzzese, T .

PHARMACOLOGICAL RESEARCH, 2001, 44 (02) :141-147

[26] REGULATION OF UTERINE ESTROGEN-RECEPTORS (ER) BY BETA-ADRENERGIC STIMULATION IN IMMATURE RATS [J].

RE, G ;

BADINO, P ;

DACASTO, M ;

DICARLO, F ;

GIRARDI, C .

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 1993, 16 (03) :328-334

[27] Effect of dietary clenbuterol and cimaterol on muscle composition, β-adrenergic and androgen receptor concentrations in broiler chickens [J].

Schiavone, A ;

Tarantola, M ;

Perona, G ;

Pagliasso, S ;

Badino, P ;

Odore, R ;

Cuniberti, B ;

Lussiana, C .

JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION, 2004, 88 (3-4) :94-100

[28] Detection of illegal growth promoters in biological samples using receptor binding assays [J].

Scippo, ML ;

Van de Weerdt, C ;

Willemsen, P ;

François, JM ;

Rentier-Delrue, F ;

Muller, M ;

Martial, JA ;

Maghuin-Rogister, G .

ANALYTICA CHIMICA ACTA, 2002, 473 (1-2) :135-141

[29]

Sola S. C., 1996, European Journal of Veterinary Pathology, V2, P87

[30]

Sporano V, 1998, VET HUM TOXICOL, V40, P141

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