Carbonylative Sonogashira coupling of terminal alkynes with aqueous ammonia

被引：173

作者：

Ahmed, MSM ^{[1
]}

Mori, A ^{[1
]}

机构：

[1] Tokyo Inst Technol, Chem Resources Lab, Yokohama, Kanagawa 2268503, Japan

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 17期

关键词：

D O I：

10.1021/ol035007a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

graphic Carbonylative coupling of phenylethyne with 4-methoxy-1-iodobenzene in the presence of 1 mol % PdCl2(PPh3)2, 2 equiv of 0.5 M aqueous ammonia, and CO (1 atm) gives the corresponding alpha,beta-alkynyl ketone in 72% isolated yield after stirring at room temperature for 41 h, while noncarbonylative coupling product is not obtained.

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页码：3057 / 3060

页数：4

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