Genes that mediate breast cancer metastasis to lung

被引：2300

作者：

Minn, AJ

Gupta, GP

Siegel, PM

Bos, PD

Shu, WP

Giri, DD

Viale, A

Olshen, AB

Gerald, WL

Massagué, J

机构：

[1] Mem Sloan Kettering Canc Ctr, Canc Biol & Genet Program, New York, NY 10021 USA

[2] Mem Sloan Kettering Canc Ctr, Dept Radiat Oncol, New York, NY 10021 USA

[3] Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA

[4] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA

[5] Mem Sloan Kettering Canc Ctr, Genom Core Lab, New York, NY 10021 USA

[6] Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, New York, NY 10021 USA

来源：

NATURE | 2005年 / 436卷 / 7050期

关键词：

D O I：

10.1038/nature03799

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

By means of in vivo selection, transcriptomic analysis, functional verification and clinical validation, here we identify a set of genes that marks and mediates breast cancer metastasis to the lungs. Some of these genes serve dual functions, providing growth advantages both in the primary tumour and in the lung microenvironment. Others contribute to aggressive growth selectively in the lung. Many encode extracellular proteins and are of previously unknown relevance to cancer metastasis.

引用

页码：518 / 524

页数：7

共 33 条

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