Regulation of glomerular volume in normal and partially nephrectomized rats

被引:41
作者
Cortes, P
Zhao, XY
Riser, BL
Narins, RG
机构
来源
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL FLUID AND ELECTROLYTE PHYSIOLOGY | 1996年 / 270卷 / 02期
关键词
glomerular compliance; remnant kidney; glomerulosclerosis; mesangial cells; mesangium;
D O I
10.1152/ajprenal.1996.270.2.F356
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Glomerular extracellular matrix accumulation may derive from the stretching of mesangial cells caused by excessive glomerular dilatation. The relationship of glomerular volume (V-G) to intraglomerular pressure, expressed as compliance or as mean V-G in the isolated, perfused rat glomerulus, was used to analyze factors that regulate V-G. Glomeruli were highly distensible over the normal and relevant abnormal range of pressure. Compliance increased directly with basal V-G (P < 0.001), i.e., larger glomeruli dilated more than smaller ones at any given pressure. Perfusion with atrial natriuretic peptide did not alter compliance, and inhibitors of nitric oxide synthesis exerted only a trivial effect. V-G expansion was consistently reduced by angiotensin II, but this effect was small (3.8%, P < 0.001). After subtotal nephrectomy, compliance increased by 59% in the remnant glomeruli (P < 0.001); 22% of this increase was attributable to structural changes, and the remainder was attributable to the large basal V-G of the hypertrophied glomeruli. Thus the major determinants of V-G expansion include capillary wall tension, basal V-G, and intrinsic distensibility, which is markedly influenced by the character of the extracellular matrix and only slightly altered by an angiotensin II-modified mesangial cell tone.
引用
收藏
页码:F356 / F370
页数:15
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