Single-dose pharmacokinetics of ofloxacin during continuous venovenous hemofiltration in critical care patients

被引：11

作者：

Fuhrmann, V ^{[1
]}

Schenk, P ^{[1
]}

Mittermayer, C ^{[1
]}

El Menyawi, I ^{[1
]}

Ratheiser, K ^{[1
]}

Thalhammer, F ^{[1
]}

机构：

[1] Univ Vienna, Allgemeines Krankenhaus, Dept Internal Med 4, Intens Care Unit, Vienna, Austria

来源：

AMERICAN JOURNAL OF KIDNEY DISEASES | 2003年 / 42卷 / 02期

关键词：

multiple organ failure; renal replacement therapy (RRT); continuous venovenous hemofiltration (CVVH); polysulfone capillary hemofilter; pharmacokinetics; ofloxacin;

D O I：

10.1016/S0272-6386(03)00656-5

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Background. Ofloxacin is a quinolone administered to patients with severe infections. Pharmacokinetic data on ofloxacin in critically ill patients on renal replacement therapy are sparse and conflicting. Methods Eight patients with anuric acute renal failure were administered 400 mg of ofloxacin intravenously. The pharmacokinetics of ofloxacin was analyzed during continuous venovenous hemofiltration (CVVH) with a high-flux polysulfone membrane. Serum and ultrafiltrate levels of ofloxacin were measured by means of high-performance liquid chromatography. Results: Mean serum ofloxacin concentration peak was 5.5 +/- 0.7 mg/L. Elimination half-life, hemofiltration clearance, and total removal were 2.8 +/- 0.5 hours, 89.9 +/- 4.5 mL/min, and 76.9% +/- 7.1%, respectively. Conclusion: Ofloxacin is significantly and rapidly eliminated by CVVH with a high-flux polysulfone membrane.

引用

页码：310 / 314

页数：5