Facilitatory and inhibitory effects of harmaline on the tryptophan-induced 5-hydroxytryptamine syndrome and body temperature changes in pargyline-pretreated rats

被引:13
作者
AbdelFattah, AFM
Matsumoto, K
Murakami, Y
ElHady, KAW
Mohamed, MF
Watanabe, H
机构
[1] TOYAMA MED & PHARMACEUT UNIV, RES INST WAKAN YAKU ORIENTAL MED, DIV PHARMACOL, SUGITANI, TOYAMA 93001, JAPAN
[2] SUEZ CANAL UNIV, FAC VET MED, DEPT PHARMACOL & TOXICOL, ISMAILIA, EGYPT
关键词
harmaline; tryptophan; pargyline; 5-hydroxytryptamine syndrome; body temperature;
D O I
10.1254/jjp.72.39
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The effects of harmaline on tryptophan-induced 5-hydroxytryptamine (5-HT) syndrome and body temperature changes in pargyline-pretreated rats were investigated. When administered i.p. 60 min after pargyline treatment (50 mg/kg, i.p.), tryptophan, at 100 mg/kg but not 10 mg/kg, induced the 5-HT syndrome. Tryptophan at 100 mg/kg also produced hypothermia followed by hyperthermia in pargyline-pretreated rats. Administration of harmaline (10 mg/kg, i.p.) 30 min after pargyline not only potentiated the 100 mg/kg tryptophan-induced 5-HT syndrome and body temperature changes, but also produced the syndrome following administration of 10 mg/kg tryptophan in pargyline-pretreated rats. In contrast, when administered 30 min before pargyline, 10 mg/kg harmaline completely suppressed the syndrome and body temperature changes caused by 100 mg/kg tryptophan. Tryptophan (100 mg/kg, i.p.) administration significantly increased 5-HT levels and decreased 5-hydroxyindole acetic acid levels and 5-HT turnover in the brain of pargyline-pretreated rats. Harmaline administration 30 min after pargyline did not significantly affect the tryptophan-induced changes in 5-HT levels and 5-HT turnover, whereas when administered 30 min before pargyline, harmaline significantly blocked the effect of tryptophan. These results suggest that mechanisms underlying the inhibitory action of harmaline on the tryptophan-induced 5-HT syndrome and body temperature changes in pargyline-pretreated rats differ from those by which harmaline potentiates the effects of tryptophan.
引用
收藏
页码:39 / 47
页数:9
相关论文
共 33 条
[1]  
AIRAKSINEN MM, 1981, MED BIOL, V59, P190
[2]   REM-SLEEP DEPRIVATION DECREASES APOMORPHINE-INDUCED STIMULATION OF LOCOMOTOR-ACTIVITY BUT NOT STEREOTYPED BEHAVIOR IN MICE [J].
ASAKURA, W ;
MATSUMOTO, K ;
OHTA, H ;
WATANABE, H .
GENERAL PHARMACOLOGY, 1992, 23 (03) :337-341
[3]   SEX-DIFFERENCES IN BEHAVIORAL AND THERMAL RESPONSES TO PARGYLINE AND TRYPTOPHAN [J].
BIEGON, A ;
SEGAL, M ;
SAMUEL, D .
PSYCHOPHARMACOLOGY, 1979, 61 (01) :77-80
[4]  
BRUINVELS J, 1968, EUR J PAHRM, V4, P13
[5]   INHIBITION BY BETA-CARBOLINES OF MONOAMINE UPTAKE INTO A SYNAPTOSOMAL PREPARATION - STRUCTURE-ACTIVITY-RELATIONSHIPS [J].
BUCKHOLTZ, NS ;
BOGGAN, WO .
LIFE SCIENCES, 1977, 20 (12) :2093-2099
[6]   INVESTIGATION ON CENTRAL EFFECTS OF HARMINE, HARMALINE AND RELATED BETA-CARBOLINES [J].
FUENTES, JA ;
LONGO, VG .
NEUROPHARMACOLOGY, 1971, 10 (01) :15-&
[7]  
FULLER RW, 1985, J PHARMACOL EXP THER, V232, P696
[8]   SEROTONIN RECEPTOR INTERACTIONS OF HARMALINE AND SEVERAL RELATED BETA-CARBOLINES [J].
GLENNON, RA .
LIFE SCIENCES, 1981, 29 (08) :861-865
[9]   BETA-CARBOLINES AS SELECTIVE MONOAMINE-OXIDASE INHIBITORS - INVIVO IMPLICATIONS [J].
GLOVER, V ;
LIEBOWITZ, J ;
ARMANDO, I ;
SANDLER, M .
JOURNAL OF NEURAL TRANSMISSION, 1982, 54 (3-4) :209-218
[10]   EFFECTS OF CENTRALLY ACTING DRUGS ON TREMOR IN MONKEYS WITH MESENCEPHALIC LESIONS [J].
GOLDSTEIN, M ;
BATTISTA, AF ;
NAKATANI, S ;
ANAGNOSTE, B .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1969, 63 (04) :1113-+