Praziquantel and Schistosomiasis

被引：57

作者：

Doemling, A. ^{[1
,2
,3
]}

Khoury, K. ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Pharm, Pittsburgh, PA 15260 USA

[2] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA

[3] Univ Pittsburgh, Dept Computat Biol, Pittsburgh, PA 15260 USA

来源：

CHEMMEDCHEM | 2010年 / 5卷 / 09期

关键词：

chemical biology; helminths; neglected tropical diseases; praziquantel; synthesis; FEMALE GENITAL SCHISTOSOMIASIS; ACYLIMINIUM ION CYCLIZATION; ANTHELMINTIC ACTIVITY; TROPICAL DISEASES; DRUG; MANSONI; SUSCEPTIBILITY; TRANSMISSION; INFECTION; COMPLEX;

D O I：

10.1002/cmdc.201000202

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

One in 30 people (∼200 million people worldwide) are infected by schistosomiasis, a predominantly African disease, which kills more than 200000 people each year. Given our ongoing interest in neglected diseases and drugs for their treatment, we provide herein the first comprehensive and detailed summary of the chemistry and biology of the antischistosomiasis drug praziquantel (1). © 2010 Wiley-VCH Verlag GmbH& Co. KGaA.

引用

页码：1420 / 1434

页数：15

共 66 条

[1]

An unusual association: vulval schistosomiasis, microinvasive vulval squamous cell carcinoma and high-grade vulval intraepithelial neoplasia in HIV patient [J].