Getting to the site of inflammation: the leukocyte adhesion cascade updated

被引:3158
作者
Ley, Klaus [1 ]
Laudanna, Carlo
Cybulsky, Myron I.
Nourshargh, Sussan
机构
[1] Univ Virginia, Robert M Berne Cardiovasc Res Ctr, Charlottesville, VA 22908 USA
[2] Univ Virginia, Dept Biomed Engn, Charlottesville, VA 22908 USA
[3] Univ Virginia, Dept Mol Physiol, Charlottesville, VA 22908 USA
[4] Univ Virginia, Dept Biol Phys, Charlottesville, VA 22908 USA
[5] Univ Verona, Dept Pathol, I-37134 Verona, Italy
[6] Univ Verona, Dept Pathol, I-37134 Verona, Italy
[7] Univ Verona, Ctr Biomed Comp, I-37134 Verona, Italy
[8] Univ Toronto, Toronto Gen Res Inst, Toronto, ON M5G 1L7, Canada
[9] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5G 1L7, Canada
[10] William Harvey Res Inst, Ctr Microvasc Res, London EC1M 68Q, England
基金
英国惠康基金;
关键词
D O I
10.1038/nri2156
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Neutrophil recruitment, lymphocyte recirculation and monocyte trafficking all require adhesion and transmigration through blood-vessel walls. The traditional three steps of rolling, activation and firm adhesion have recently been augmented and refined. Slow rolling, adhesion strengthening, intraluminal crawling and paracellular and transcellular migration are now recognized as separate, additional steps. In neutrophils, a second activation pathway has been discovered that does not require signalling through G-protein-coupled receptors and the signalling steps leading to integrin activation are beginning to emerge. This Review focuses on new aspects of one of the central paradigms of inflammation and immunity - the leukocyte adhesion cascade.
引用
收藏
页码:678 / 689
页数:12
相关论文
共 135 条
[111]   Leukocyte phosphoinositide-3 kinase γ is required for chemokine-induced, sustained adhesion under flow in vivo [J].
Smith, David F. ;
Deem, Tracy L. ;
Bruce, Anthony C. ;
Reutershan, Jorg ;
Wu, Daniel ;
Ley, Klaus .
JOURNAL OF LEUKOCYTE BIOLOGY, 2006, 80 (06) :1491-1499
[112]   P-selectin glycoprotein ligand-1 mediates L-selectin-dependent leukocyte rolling in venules [J].
Sperandio, M ;
Smith, ML ;
Forlow, SB ;
Olson, TS ;
Xia, LJ ;
McEver, RP ;
Ley, K .
JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (10) :1355-1363
[113]   TRAFFIC SIGNALS ON ENDOTHELIUM FOR LYMPHOCYTE RECIRCULATION AND LEUKOCYTE EMIGRATION [J].
SPRINGER, TA .
ANNUAL REVIEW OF PHYSIOLOGY, 1995, 57 :827-872
[114]   FUNCTIONAL CLONING OF ICAM-2, A CELL-ADHESION LIGAND FOR LFA-1 HOMOLOGOUS TO ICAM-1 [J].
STAUNTON, DE ;
DUSTIN, ML ;
SPRINGER, TA .
NATURE, 1989, 339 (6219) :61-64
[115]   Acceleration of the onset of collagen-induced arthritis by a deficiency of platelet endothelial cell adhesion molecule 1 [J].
Tada, Y ;
Koarada, S ;
Morito, F ;
Ushiyama, O ;
Haruta, Y ;
Kanegae, F ;
Ohta, A ;
Ho, A ;
Mak, TW ;
Nagasawa, K .
ARTHRITIS AND RHEUMATISM, 2003, 48 (11) :3280-3290
[116]   Talin binding to integrin β tails:: A final common step in integrin activation [J].
Tadokoro, S ;
Shattil, SJ ;
Eto, K ;
Tai, V ;
Liddington, RC ;
de Pereda, JM ;
Ginsberg, MH ;
Calderwood, DA .
SCIENCE, 2003, 302 (5642) :103-106
[117]   Platelet-endothelial cell adhesion molecule-1 (PECAM-1)-deficient mice demonstrate a transient and cytokine-specific role for PECAM-1 in leukocyte migration through the perivascular basement membrane [J].
Thompson, RD ;
Noble, KE ;
Larbi, KY ;
Dewar, A ;
Duncan, GS ;
Mak, TW ;
Nourshargh, S .
BLOOD, 2001, 97 (06) :1854-1860
[118]   ITAM-based interaction of ERM proteins with Syk mediates signaling by the leukocyte adhesion receptor PSGL-1 [J].
Urzainqui, A ;
Serrador, JM ;
Viedma, F ;
Yáñez-Mó, M ;
Rodríguez, A ;
Corbí, AL ;
Alonso-Lebrero, JL ;
Luque, A ;
Deckert, M ;
Vázquez, J ;
Sánchez-Madrid, F .
IMMUNITY, 2002, 17 (04) :401-412
[119]  
Vajkoczy P, 2001, J CLIN INVEST, V108, P557
[120]   Regulation of endothelial cell contacts during leukocyte extravasation [J].
Vestweber, D .
CURRENT OPINION IN CELL BIOLOGY, 2002, 14 (05) :587-593