Efficacy of three screening instruments in the identification of autistic-spectrum disorders

被引:185
作者
Charman, Tony [1 ]
Baird, Gillian [2 ]
Simonoff, Emily [3 ]
Loucas, Tom [4 ]
Chandler, Susie [1 ]
Meldrum, David [5 ]
Pickles, Andrew [6 ]
机构
[1] UCL, Inst Child Hlth, Behav & Brain Sci Unit, London WC1E 6BT, England
[2] Guys & St Thomas NHS Fdn Trust, London, England
[3] Kings Coll London, Inst Psychiat, London, England
[4] Univ Reading, Sch Psychol & Clin Language Sci, Reading RG6 2AH, Berks, England
[5] Chatswood Assessment Ctr, Sydney, NSW, Australia
[6] Univ Manchester, Div Epidemiol & Hlth Sci, Manchester M13 9PL, Lancs, England
关键词
D O I
10.1192/bjp.bp.107.040196
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Background Screening instruments for autistic-spectrum disorders have not been compared in the same sample. Aims To compare the Social Communication Questionnaire (SCQ), the Social Responsiveness Scale (SRS) and the Children's Communication Checklist (CCC). Method Screen and diagnostic assessments on 119 children between 9 and 13 years of age with special educational needs with and without autistic-spectrum disorders were weighted to estimate screen characteristics for a realistic target population. Results The SCQ performed best (area under receiver operating characteristic curve (AUC)=0.90; sensitivity. 6; specificity 0.78). The SRS had a lower AUC (0.77) with high sensitivity (0.78) and moderate specificity (0.67). The CCC had a high sensitivity but lower specificity (AUC=0.79; sensitivity 0.93; specificity 0.46). The AUC of the SRS and CCC was lower for children with IQ < 70. Behaviour problems reduced specificity for all three instruments. Conclusions The SCQ, SRS and CCC showed strong to moderate ability to identify autistic-spectrum disorder in this at-risk sample of school-age children with special educational needs.
引用
收藏
页码:554 / 559
页数:6
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