The TOMMY trial: a comparison of TOMosynthesis with digital MammographY in the UK NHS Breast Screening Programme a multicentre retrospective reading study comparing the diagnostic performance of digital breast tomosynthesis and digital mammography with digital mammography alone

被引：136

作者：

Gilbert, Fiona J. ^{[1
]}

Tucker, Lorraine ^{[1
]}

Gillan, Maureen G. C. ^{[2
]}

Willsher, Paula ^{[1
]}

Cooke, Julie ^{[3
]}

Duncan, Karen A. ^{[4
]}

Michell, Michael J. ^{[5
]}

Dobson, Hilary M. ^{[6
]}

Lim, Yit Yoong ^{[7
]}

Purushothaman, Hema ^{[8
]}

Strudley, Celia ^{[9
]}

Astley, Susan M. ^{[10
]}

Morrish, Oliver ^{[11
]}

Young, Kenneth C. ^{[9
]}

Duffy, Stephen W. ^{[12
]}

机构：

[1] Univ Cambridge, Dept Radiol, Cambridge, England

[2] Univ Aberdeen, Aberdeen Biomed Imaging Ctr, Aberdeen, Scotland

[3] Jarvis Breast Ctr, Guildford, Surrey, England

[4] North East Scotland Breast Screening Ctr, Aberdeen, Scotland

[5] Kings Coll Hosp London, London, England

[6] West Scotland Breast Screening Serv, Glasgow, Lanark, Scotland

[7] Univ S Manchester Hosp, Nightingale Ctr, Manchester M20 8LR, Lancs, England

[8] St Bartholomews Hosp, Dept Radiol, London, England

[9] Royal Surrey Cty Hosp, Natl Coordinating Ctr Phys Mammog, Guildford, Surrey, England

[10] Univ Manchester, Dept Imaging Sci & Biomed Engn, Manchester, Lancs, England

[11] Cambridge Univ Hosp, East Anglian Reg Radiat Protect Serv, Cambridge, England

[12] Queen Mary Univ London, Wolfson Inst Prevent Med, London, England

来源：

HEALTH TECHNOLOGY ASSESSMENT | 2015年 / 19卷 / 04期

关键词：

RECONSTRUCTED PROJECTION IMAGES; REPLACEMENT THERAPY USE; CANCER RISK; PARENCHYMAL PATTERNS; INITIAL-EXPERIENCE; TISSUE COMPOSITION; SUBSEQUENT RISK; FAMILY-HISTORY; DENSITY; WOMEN;

D O I：

10.3310/hta19040

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Breast screening with mammography is recognised as the most effective method of detecting early-stage breast cancer and reducing breast cancer mortality. A recent meta-analysis of 11 randomised trials concluded that there was a 20% relative risk reduction in breast cancer mortality in women invited to screening. 1 However, one of the primary limitations of standard two-dimensional (2D) mammography is that overlapping dense fibroglandular tissue within the breast can decrease the visibility of malignant abnormalities or simulate the appearance of an abnormality. This reduces the sensitivity of screening and increases the number of false-positive recalls. 2 It has been shown that 15-30% of cancers are not detected by standard screening, 3 and this percentage is higher in women aged under 50 years4 and in women with dense breasts. 5-7 Women with dense breasts have reduced screening programme sensitivity8-11 and tend to have larger screen-detected and interval cancers. 8,12,13 These issues are of concern for the UK NHS Breast Screening Programme (NHSBSP) as it extends the screening age range to include younger, pre-or perimenopausal women who are known to have a higher proportion of dense breast tissue14,15 and is also potentially problematic for women at moderate or high risk of developing familial breast cancer who

引用

页码：1 / +

页数：138

共 150 条

[1]

AETNA, AETNA CLIN POL B MAM

[2] Association between mammographic breast density and breast cancer tumor characteristics [J].