New cytotoxic saturated and unsaturated cyclohexanones from Anthemis maritimaii

被引：20

作者：

Collu, Francesca ^{[1
]}

Bonsignore, Leonardo ^{[1
]}

Casu, Mariano ^{[2
]}

Floris, Costantino ^{[2
]}

Gertsch, Juerg ^{[3
]}

Cottiglia, Filippo ^{[1
]}

机构：

[1] Univ Cagliari, Dipartimento Farmaco Chim Tecnol, I-09124 Cagliari, Italy

[2] Univ Cagliari, Dipartimento Sci Chim, I-09042 Monserrato, Italy

[3] Swiss Fed Inst Technol, Inst Pharmaceut Sci, Zurich, Switzerland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 05期

关键词：

Anthemis maritima; cyclohexenones; cytotoxic activity; NMR; glutathione;

D O I：

10.1016/j.bmcl.2008.01.078

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new cyclohexenones (antheminones A and B) and a new cyclohexanone, (antheminone C) along with five known compounds were isolated from the leaves of Anthemis maritima L. The structures were mainly deduced from extensive 1D and 2D NMR spectroscopy and mass spectrometry. The new compounds were tested in vitro for their cytotoxic activity against adherent and non-adherent cancer cell lines. Antheminones A and C exhibited significant antiproliferative activity against leukemia cells with IC50 values ranging from 3.2 to 14 mu M. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1559 / 1562

页数：4

共 19 条

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