The Role of Costimulatory Receptors of the Tumour Necrosis Factor Receptor Family in Atherosclerosis

被引：10

作者：

Antunes, Ricardo F. ^{[1
]}

Kaski, Juan Carlos ^{[1
]}

Dumitriu, Ingrid E. ^{[1
]}

机构：

[1] St Georges Univ London, Div Clin Sci, London SW17 0RE, England

来源：

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY | 2012年

关键词：

T-CELL-ACTIVATION; VASCULAR ENDOTHELIAL-CELLS; ENHANCED PLASMA-LEVELS; SMOOTH-MUSCLE-CELLS; SOLUBLE CD40 LIGAND; OX40; LIGAND; TNF-RECEPTOR; UNSTABLE ANGINA; MONOCLONAL-ANTIBODY; IN-VITRO;

D O I：

10.1155/2012/464532

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Atherosclerosis is a chronic inflammatory disease that is mediated by both the innate and adaptive immune responses. T lymphocytes, that together with B cells are the cellular effectors of the adaptive immune system, are currently endowed with crucial roles in the development and progression of atherosclerosis. Costimulatory receptors are a class of molecules expressed by T lymphocytes that regulate the activation of T cells and the generation of effector T-cell responses. In this review we present the roles of costimulatory receptors of the tumour necrosis factor receptor (TNFR) superfamily in atherosclerosis and discuss the implications for future therapies that could be used to specifically modulate the immune response of pathogenic T cells in this disease.

引用

页数：16

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