An Overview of Three Promising Mechanical, Optical, and Biochemical Engineering Approaches to Improve Selective Photothermolysis of Refractory Port Wine Stains

被引:74
作者
Aguilar, Guillermo [2 ]
Choi, Bernard [3 ,4 ]
Broekgaarden, Mans [1 ,5 ]
Yang, Owen [3 ,4 ]
Yang, Bruce [3 ,4 ]
Ghasri, Pedram [3 ]
Chen, Jennifer K. [3 ]
Bezemer, Rick [6 ]
Nelson, J. Stuart [3 ,4 ]
van Drooge, Anne Margreet
Wolkerstorfer, Albert
Kelly, Kristen M. [3 ]
Heger, Michal [1 ,5 ]
机构
[1] Univ Amsterdam, Acad Med Ctr, Dept Expt Surg, NL-1105 AZ Amsterdam, Netherlands
[2] Univ Calif Riverside, Dept Mech Engn, Riverside, CA 92521 USA
[3] Univ Calif Irvine, Beckman Laser Inst & Med Clin, Irvine, CA 92715 USA
[4] Univ Calif Irvine, Dept Biomed Engn, Irvine, CA 92715 USA
[5] Univ Utrecht, Inst Biomembranes, Utrecht, Netherlands
[6] Univ Amsterdam, Acad Med Ctr, Dept Translat Physiol, NL-1105 AZ Amsterdam, Netherlands
关键词
Vascular malformations; Dermis; Suboptimal therapeutic response and lesional recalcitrance; Hypobaric pressure; Suction cup; Blood flow; Laser speckle imaging; Site-specific pharmaco-laser therapy; Liposomal drug delivery system; PULSED-DYE-LASER; STERICALLY STABILIZED LIPOSOMES; TEMPERATURE-SENSITIVE LIPOSOMES; TISSUE-PLASMINOGEN-ACTIVATOR; TRANEXAMIC ACID; BLOOD-VESSELS; HUMAN SKIN; PHOTODYNAMIC THERAPY; VASCULAR-LESIONS; THERMAL RESPONSE;
D O I
10.1007/s10439-011-0436-9
中图分类号
R318 [生物医学工程];
学科分类号
100103 [病原生物学];
摘要
During the last three decades, several laser systems, ancillary technologies, and treatment modalities have been developed for the treatment of port wine stains (PWSs). However, approximately half of the PWS patient population responds suboptimally to laser treatment. Consequently, novel treatment modalities and therapeutic techniques/strategies are required to improve PWS treatment efficacy. This overview therefore focuses on three distinct experimental approaches for the optimization of PWS laser treatment. The approaches are addressed from the perspective of mechanical engineering (the use of local hypobaric pressure to induce vasodilation in the laser-irradiated dermal microcirculation), optical engineering (laser-speckle imaging of post-treatment flow in laser-treated PWS skin), and biochemical engineering (light- and heat-activatable liposomal drug delivery systems to enhance the extent of post-irradiation vascular occlusion).
引用
收藏
页码:486 / 506
页数:21
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