Cell adhesion, cell junctions and the blood brain barrier

被引：91

作者：

Staddon, JM

Rubin, LL

机构：

[1] Eisai London Res. Laboratories Ltd, Bernard Katz Building, University College London, London WC1E 6BT, Gower Street

来源：

CURRENT OPINION IN NEUROBIOLOGY | 1996年 / 6卷 / 05期

关键词：

D O I：

10.1016/S0959-4388(96)80094-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The blood-brain barrier regulates the movement of molecules and cells between the circulation and the CNS. Modulation of this barrier may be critical in the aetiology of various CNS pathologies. Endothelial cell tight junctions are an essential part of the barrier, and recent advances have been made in understanding how specific intracellular signalling events regulate cell-cell adhesion and tight-junction permeability.

引用

页码：622 / 627

页数：6

共 52 条

[31] LYSOPHOSPHATIDIC ACID, A MULTIFUNCTIONAL PHOSPHOLIPID MESSENGER [J].

MOOLENAAR, WH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (22) :12949-12952

[32] RHO-PROTEIN REGULATES TIGHT JUNCTIONS AND PERIJUNCTIONAL ACTIN ORGANIZATION IN POLARIZED EPITHELIA [J].

NUSRAT, A ;

GIRY, M ;

TURNER, JR ;

COLGAN, SP ;

PARKOS, CA ;

CARNES, D ;

LEMICHEZ, E ;

BOQUET, P ;

MADARA, JL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (23) :10629-10633

[33] CEREBRAL MICROVASCULAR ENDOTHELIAL-CELL NA-K-CL COTRANSPORT - REGULATION BY ASTROCYTE-CONDITIONED MEDIUM [J].

ODONNELL, ME ;

MARTINEZ, A ;

SUN, DD .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 1995, 268 (03) :C747-C754

[34] A REPEATING AMINO-ACID MOTIF SHARED BY PROTEINS WITH DIVERSE CELLULAR ROLES [J].

PEIFER, M ;

BERG, S ;

REYNOLDS, AB .

CELL, 1994, 76 (05) :789-791

[35] MOUSE MULTIDRUG-RESISTANCE 1A/3 GENE IS THE EARLIEST KNOWN ENDOTHELIAL-CELL DIFFERENTIATION MARKER DURING BLOOD-BRAIN-BARRIER DEVELOPMENT [J].

QIN, Y ;

SATO, TN .

DEVELOPMENTAL DYNAMICS, 1995, 202 (02) :172-180

[36] IDENTIFICATION OF A NEW CATENIN - THE TYROSINE KINASE SUBSTRATE P120(CAS) ASSOCIATES WITH E-CADHERIN COMPLEXES [J].

REYNOLDS, AB ;

DANIEL, J ;

MCCREA, PD ;

WHEELOCK, MJ ;

WU, J ;

ZHANG, Z .

MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (12) :8333-8342

[37] DIFFERENTIATION OF ENDOTHELIUM [J].

RISAU, W .

FASEB JOURNAL, 1995, 9 (10) :926-933

[38] A CELL-CULTURE MODEL OF THE BLOOD-BRAIN-BARRIER [J].

RUBIN, LL ;

HALL, DE ;

PORTER, S ;

BARBU, K ;

CANNON, C ;

HORNER, HC ;

JANATPOUR, M ;

LIAW, CW ;

MANNING, K ;

MORALES, J ;

TANNER, LI ;

TOMASELLI, KJ ;

BARD, F .

JOURNAL OF CELL BIOLOGY, 1991, 115 (06) :1725-1735

[39] DISTINCT ROLES OF THE RECEPTOR TYROSINE KINASES TIE-1 AND TIE-2 IN BLOOD-VESSEL FORMATION [J].

SATO, TN ;

TOZAWA, Y ;

DEUTSCH, U ;

WOLBURGBUCHHOLZ, K ;

FUJIWARA, Y ;

GENDRONMAGUIRE, M ;

GRIDLEY, T ;

WOLBURG, H ;

RISAU, W ;

QIN, Y .

NATURE, 1995, 376 (6535) :70-74

[40] DISRUPTION OF THE MOUSE MDR1A P-GLYCOPROTEIN GENE LEADS TO A DEFICIENCY IN THE BLOOD-BRAIN-BARRIER AND TO INCREASED SENSITIVITY TO DRUGS [J].

SCHINKEL, AH ;

SMIT, JJM ;

VANTELLINGEN, O ;

BEIJNEN, JH ;

WAGENAAR, E ;

VANDEEMTER, L ;

MOL, CAAM ;

VANDERVALK, MA ;

ROBANUSMAANDAG, EC ;

TERIELE, HPJ ;

BERNS, AJM ;

BORST, P .

CELL, 1994, 77 (04) :491-502

← 1 2 3 4 5 6 →