Intracoronary delivery of bone-marrow-derived stem cells

被引：27

作者：

Bui, Quang T.

Gertz, Zachary M.

Wilensky, Robert L. ^{[1
]}

机构：

[1] Hosp Univ Penn, Div Cardiovasc, Philadelphia, PA 19104 USA

来源：

STEM CELL RESEARCH & THERAPY | 2010年 / 1卷

关键词：

ACUTE MYOCARDIAL-INFARCTION; LEFT-VENTRICULAR FUNCTION; THERAPY; REPAIR; TRANSPLANTATION; INFUSION; HEART; REGENERATION; INJECTION; BENEFIT;

D O I：

10.1186/scrt29

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Ischemic heart disease is the single greatest killer of Americans and its complications are a major cause of congestive heart failure and ventricular arrhythmias while significantly contributing to increased health care costs and reduced patient quality of life. Advances in medical therapy, although significant over the past decade, are still inadequate in regards to targeting the prime underlying pathology, the irreversible loss of damaged or dead cardiomyocytes. Research into the use of cell transplantation therapy to treat cardiac diseases, with the goal of improving cardiac function, shows promise. The aim of this review will be to discuss the potential therapeutic effects of myocardial stem cell and progenitor cell therapy delivered by an intracoronary route with special reference to treatment of infarcted myocardium.

引用

页数：7

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