Synthesis of a highly functionalized rigid template by solid phase azomethine ylide cycloaddition

被引：29

作者：

Bicknell, AJ ^{[1
]}

Hird, NW ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,HARLOW CM19 5AD,ESSEX,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 20期

关键词：

D O I：

10.1016/0960-894X(96)00447-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 1,5-diazabicyclo[3.3.0]octane-2-carboxylic acids have been synthesized in good yields and purities via cycloaddition of maleimides to polymer supported azomethine ylides. N-Acylation of the resulting cycloadduct enables the synthesis of diverse molecules based on a highly functionalized rigid template. Copyright (C) 1996 Elsevier Science Ltd.

引用

页码：2441 / 2444

页数：4

共 10 条

[1] Synthesis of an array of amides by aluminium chloride assisted cleavage of resin-bound esters
Barn, DR
Morphy, JR
Rees, DC
[J]. TETRAHEDRON LETTERS, 1996, 37 (18) : 3213 - 3216
[2] Baum R.M., 1994, C EN 0207, P20
[3] COSTERO AM, 1994, J CHEM RES-S, P316
[4] APPLICATIONS OF COMBINATORIAL TECHNOLOGIES TO DRUG DISCOVERY .1. BACKGROUND AND PEPTIDE COMBINATORIAL LIBRARIES
GALLOP, MA
BARRETT, RW
DOWER, WJ
FODOR, SPA
GORDON, EM
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (09) : 1233 - 1251
[5] APPLICATIONS OF COMBINATORIAL TECHNOLOGIES TO DRUG DISCOVERY .2. COMBINATORIAL ORGANIC-SYNTHESIS, LIBRARY SCREENING STRATEGIES, AND FUTURE-DIRECTIONS
GORDON, EM
BARRETT, RW
DOWER, WJ
FODOR, SPA
GALLOP, MA
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (10) : 1385 - 1401
[6] THE MECHANISM OF THE RACEMIZATION OF ALPHA-AMINO-ACIDS IN THE PRESENCE OF ALDEHYDES
GRIGG, R
GUNARATNE, HQN
[J]. TETRAHEDRON LETTERS, 1983, 24 (41) : 4457 - 4460
[7] Solid-phase synthesis of proline analogs via a three component 1,3-dipolar cycloaddition
Hamper, BC
Dukesherer, DR
South, MS
[J]. TETRAHEDRON LETTERS, 1996, 37 (21) : 3671 - 3674
[8] Solid-phase organic reactions: A review of the recent literature
Hermkens, PHH
Ottenheijm, HCJ
Rees, D
[J]. TETRAHEDRON, 1996, 52 (13) : 4527 - 4554
[9] COMBINATORIAL ORGANIC-SYNTHESIS OF HIGHLY FUNCTIONALIZED PYRROLIDINES - IDENTIFICATION OF A POTENT ANGIOTENSIN-CONVERTING ENZYME-INHIBITOR FROM A MERCAPTOACYL PROLINE LIBRARY
MURPHY, MM
SCHULLEK, JR
GORDON, EM
GALLOP, MA
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (26) : 7029 - 7030
[10] COMBINATORIAL SYNTHESIS - THE DESIGN OF COMPOUND LIBRARIES AND THEIR APPLICATION TO DRUG DISCOVERY
TERRETT, NK
GARDNER, M
GORDON, DW
KOBYLECKI, RJ
STEELE, J
[J]. TETRAHEDRON, 1995, 51 (30) : 8135 - 8173

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