Aspects of fungal pathogenesis in humans

被引:119
作者
van Burik, JAH [1 ]
Magee, PT
机构
[1] Univ Minnesota, Sch Med, Dept Med, Div Infect Dis, Minneapolis, MN 55455 USA
[2] Univ Minnesota, Coll Biol Sci, Dept Genet Cell Biol & Dev, St Paul, MN 55108 USA
关键词
virulence factors; primary fungal pathogens; opportunistic fungal pathogens; mucosal fungal infections; systemic fungal infections;
D O I
10.1146/annurev.micro.55.1.743
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Fungal diseases have become increasingly important in the past few years. Because few fungi are professional pathogens, fungal pathogenic mechanisms tend to be highly complex, arising in large part from adaptations of preexisting characteristics of the organisms' nonparasitic lifestyles. In the past few years, genetic approaches have elucidated many fungal virulence factors, and increasing knowledge of host reactions has also clarified much about fungal diseases. The literature on fungal pathogenesis has grown correspondingly; this review, therefore, will not attempt to provide comprehensive coverage of fungal disease but focuses on properties of the infecting fungus and interactions with the host. These topics have been chosen to make the review most useful to two kinds of readers: fungal geneticists and molecular biologists who are interested in learning about the biological problems posed by infectious diseases, and physicians who want to know the kinds of basic approaches available to study fungal virulence.
引用
收藏
页码:743 / 772
页数:30
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