Treatment of stiff person syndrome with rituximab

被引：66

作者：

Baker, MR

Das, M

Isaacs, J

Fawcett, PRW

Bates, D

机构：

[1] Royal Victoria Infirm, Dept Neurol, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England

[2] Royal Victoria Infirm, Dept Neurophysiol, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England

[3] Royal Victoria Infirm, Dept Rheumatol, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 2005年 / 76卷 / 07期

关键词：

D O I：

10.1136/jnnp.2004.051144

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This case report is about the novel use of the anti-CD20 antibody, rituximab, in the treatment of a 41 year old woman with stiff person syndrome. She was admitted to hospital as an emergency with prolonged and painful extensor spasms affecting the neck and back, arms, and legs. The disease had progressed despite a favourable initial response to conventional treatment with intravenous immunoglobulin and cytotoxics. Treatment with rituximab induced a lasting clinical remission.

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页码：999 / 1001

页数：3

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