Simultaneous determination of a camptothecin derivative, used as an anticancer drug, and its photodegradation products by high-performance liquid chromatography

被引：12

作者：

Akimoto, K

Kawai, A

Ohya, K

机构：

[1] Pharmaceutical Formulation Res. Lab., Tokyo Res. and Development Center, Daiichi Pharmaceutical Co. Ltd., Tokyo 134, 16-13 Kita-kasai 1-chome, Edogawa-ku

来源：

JOURNAL OF CHROMATOGRAPHY A | 1996年 / 734卷 / 02期

关键词：

pharmaceutical analysis; photodegradation; CPT-II; camptothecin;

D O I：

10.1016/0021-9673(96)00013-1

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A simple and rapid ion-pair high-performance liquid chromatographic method using a polymer-based column bonded octadecyl group was developed for the simultaneous determination of the anticancer drug CPT-11 and its three main photodegradation products. The analytes were detected by ultraviolet absorption at 254 nm.

引用

页码：401 / 404

页数：4

共 7 条

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