An asymmetric synthesis of (1S,4R)-4-amino-2-cyclopentenol derivatives

被引：30

作者：

Asami, M ^{[1
]}

Ogawa, M ^{[1
]}

Inoue, S ^{[1
]}

机构：

[1] Yokohama Natl Univ, Fac Engn, Dept Synthet Chem, Hodogaya Ku, Yokohama, Kanagawa 2408501, Japan

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 08期

关键词：

deprotonation; enantioselection; epoxides; rearrangement;

D O I：

10.1016/S0040-4039(99)00002-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly enantioselective deprotonation of cis-4-aminocyclopentene oxide derivatives 1 was achieved by using a chiral lithium amide, prepared from (2S,3aS,7aS)-2-(pyrrolidin-1-ylmethyl) octahydroindole, (1S,4R)-4-Amino-2-cyclopentenol derivative 2 was obtained in up to 90 % ee. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1563 / 1564

页数：2

共 12 条

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