Squaric acid is a suitable building-block in 4C-Ugi reaction: access to original bivalent compounds

被引：20

作者：

Aknin, Karen

Gauriot, Marion

Totobenazara, Jane

Deguine, Noemie

Deprez-Poulain, Rebecca

Deprez, Benoit

Charton, Julie ^{[1
]}

机构：

[1] INSERM U761 Biostruct & Drug Discovery, F-59000 Lille, France

来源：

TETRAHEDRON LETTERS | 2012年 / 53卷 / 04期

关键词：

Squaric acid; 4C-Ugi reaction; Bivalent compounds; MULTICOMPONENT REACTIONS; LIGANDS; POTENT; INHIBITORS; DERIVATIVES; ANTAGONISTS; DESIGN; CXCR2; SAR;

D O I：

10.1016/j.tetlet.2011.11.077

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The 4C-Ugi reaction requires an acidic component as one of the building-blocks. We report here the first use of squaric acid for this reaction to access original symmetrical compounds. The scope and conditions of the reaction were explored. (C) 2011 Elsevier Ltd. All rights reserved.

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页码：458 / 461

页数：4

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