Recent developments in isocyanide based multicomponent reactions in applied chemistry

被引：4150

作者：

Dömling, A ^{[1
]}

机构：

[1] ABC Pharm, D-81243 Munich, Germany

来源：

CHEMICAL REVIEWS | 2006年 / 106卷 / 01期

关键词：

D O I：

10.1021/cr0505728

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Multicomponent reactions (MCRs) are reactions where more than two starting materials react to form a product, incorporating all of the atoms of the educts. These reactions are classified according to the reaction mechanisms, the components involved, or their intrinsic variability. This paper discusses stereocontrol in MCRs, novel isocyanide based MCRs (IMCRs), applications of MCRs in drug discovery, MCRs in natural product synthesis, and miscellaneous applications of IMCRs.

引用

页码：17 / 89

页数：73

共 324 条

[1] A versatile synthesis of fused triazolo derivatives by sequential Ugi/alkyne-azide cycloaddition reactions
Akritopoulou-Zanze, I
Gracias, V
Djuric, SW
[J]. TETRAHEDRON LETTERS, 2004, 45 (46) : 8439 - 8441
[2] Synthesis of novel fused isoxazoles and isoxazolines by sequential Ugi/INOC reactions
Akritopoulou-Zanze, I
Gracias, V
Moore, JD
Djuric, SW
[J]. TETRAHEDRON LETTERS, 2004, 45 (17) : 3421 - 3423
[3] ALIG L, 2003, Patent No. 2003066588
[4] ALLA S, 2003, Patent No. 2003010130
[5] Studies towards the synthesis of Fipronil® analogues:: improved decarboxylation of α-hydrazonoacid derivatives
Ancel, JE
El Kaïm, L
Gadras, A
Grimaud, L
Jana, NK
[J]. TETRAHEDRON LETTERS, 2002, 43 (46) : 8319 - 8321
[6] Stereochemical control of the Passerini reaction
Andreana, PR
Liu, CC
Schreiber, SL
[J]. ORGANIC LETTERS, 2004, 6 (23) : 4231 - 4233
[7] ARMOUR DR, Patent No. 2004020414
[8] Baharfar R, 2003, J CHEM RES, P616
[9] A thymine-PNA monomer as new isocyanide component in the Ugi reaction: A direct entry to PNA dimers
Baldoli, C
Giannini, C
Licandro, E
Maiorana, S
Zinzalla, G
[J]. SYNLETT, 2004, (06) : 1044 - 1048
[10] Synthesis of chiral chromium tricarbonyl labeled thymine PNA monomers via the Ugi reaction
Baldoli, C
Maiorana, S
Licandro, E
Zinzalla, G
Perdicchia, D
[J]. ORGANIC LETTERS, 2002, 4 (24) : 4341 - 4344

← 1 2 3 4 5 6 7 8 9 10 →