Studies towards the synthesis of Fipronil® analogues:: improved decarboxylation of α-hydrazonoacid derivatives

被引：25

作者：

Ancel, JE

El Kaïm, L

Gadras, A

Grimaud, L

Jana, NK

机构：

[1] Ecole Natl Super Tech Avancees, Lab Chim & Procedes, F-75015 Paris, France

[2] CRIT Rhones Poulenc Ind, F-69153 Decines Charpieu, France

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 46期

关键词：

D O I：

10.1016/S0040-4039(02)01977-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Mannich reaction of hydrazones coupled with a [4+1] cycloaddition with isocyanides has been used for the synthesis of aminopyrazole analogues of Fipronil(R). The starting cyanohydrazone was prepared with new experimental conditions for efficient diazonium coupling in fluorinated solvents followed by a new sodium cyanide catalysed decarboxylation. (C) 2002 Published by Elsevier Science Ltd.

引用

页码：8319 / 8321

页数：3

共 4 条

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