G protein subunits;
modified guanine nucleotides;
receptor-derived peptides;
mastoparan and related venoms;
suramin analogues;
amphiphilic cations;
D O I:
10.1007/s000180050288
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
The structure and function of heterotrimeric G protein subunits is known in considerable detail. Upon stimulation of a heptahelical receptor by the appropriate agonists, the cognate G proteins undergo a cycle of activation and deactivation; the alpha-subunits and the beta gamma-dimers interact sequentially with several reaction partners (receptor, guanine nucleotides and effecters as well as regulatory proteins) by exposing appropriate binding sites. For most of these domains, low molecular weight ligands have been identified that either activate or inhibit signal transduction. These ligands include short peptides derived from receptors, G protein subunits and effecters, mastoparan and related insect venoms, modified guanine nucleotides, suramin analogues and amphiphilic cations. Because compounds that act on G proteins may be endowed with new forms of selectivity, we propose that G protein subunits may therefore be considered as potential drug targets.
机构:Duke Univ, Med Ctr, Dept Med, Howard Hughes Med Inst, Durham, NC 27710 USA
Hall, RA
Premont, RT
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机构:Duke Univ, Med Ctr, Dept Med, Howard Hughes Med Inst, Durham, NC 27710 USA
Premont, RT
Chow, CW
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机构:Duke Univ, Med Ctr, Dept Med, Howard Hughes Med Inst, Durham, NC 27710 USA
Chow, CW
Blitzer, JT
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机构:Duke Univ, Med Ctr, Dept Med, Howard Hughes Med Inst, Durham, NC 27710 USA
Blitzer, JT
Pitcher, JA
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机构:Duke Univ, Med Ctr, Dept Med, Howard Hughes Med Inst, Durham, NC 27710 USA
Pitcher, JA
Claing, A
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机构:Duke Univ, Med Ctr, Dept Med, Howard Hughes Med Inst, Durham, NC 27710 USA
Claing, A
Stoffel, RH
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机构:Duke Univ, Med Ctr, Dept Med, Howard Hughes Med Inst, Durham, NC 27710 USA
Stoffel, RH
Barak, LS
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h-index: 0
机构:Duke Univ, Med Ctr, Dept Med, Howard Hughes Med Inst, Durham, NC 27710 USA
Barak, LS
Shenolikar, S
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h-index: 0
机构:Duke Univ, Med Ctr, Dept Med, Howard Hughes Med Inst, Durham, NC 27710 USA
Shenolikar, S
Weinman, EJ
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机构:Duke Univ, Med Ctr, Dept Med, Howard Hughes Med Inst, Durham, NC 27710 USA
Weinman, EJ
Grinstein, S
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h-index: 0
机构:Duke Univ, Med Ctr, Dept Med, Howard Hughes Med Inst, Durham, NC 27710 USA
Grinstein, S
Lefkowitz, RJ
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h-index: 0
机构:
Duke Univ, Med Ctr, Dept Med, Howard Hughes Med Inst, Durham, NC 27710 USADuke Univ, Med Ctr, Dept Med, Howard Hughes Med Inst, Durham, NC 27710 USA
机构:Duke Univ, Med Ctr, Dept Med, Howard Hughes Med Inst, Durham, NC 27710 USA
Hall, RA
Premont, RT
论文数: 0引用数: 0
h-index: 0
机构:Duke Univ, Med Ctr, Dept Med, Howard Hughes Med Inst, Durham, NC 27710 USA
Premont, RT
Chow, CW
论文数: 0引用数: 0
h-index: 0
机构:Duke Univ, Med Ctr, Dept Med, Howard Hughes Med Inst, Durham, NC 27710 USA
Chow, CW
Blitzer, JT
论文数: 0引用数: 0
h-index: 0
机构:Duke Univ, Med Ctr, Dept Med, Howard Hughes Med Inst, Durham, NC 27710 USA
Blitzer, JT
Pitcher, JA
论文数: 0引用数: 0
h-index: 0
机构:Duke Univ, Med Ctr, Dept Med, Howard Hughes Med Inst, Durham, NC 27710 USA
Pitcher, JA
Claing, A
论文数: 0引用数: 0
h-index: 0
机构:Duke Univ, Med Ctr, Dept Med, Howard Hughes Med Inst, Durham, NC 27710 USA
Claing, A
Stoffel, RH
论文数: 0引用数: 0
h-index: 0
机构:Duke Univ, Med Ctr, Dept Med, Howard Hughes Med Inst, Durham, NC 27710 USA
Stoffel, RH
Barak, LS
论文数: 0引用数: 0
h-index: 0
机构:Duke Univ, Med Ctr, Dept Med, Howard Hughes Med Inst, Durham, NC 27710 USA
Barak, LS
Shenolikar, S
论文数: 0引用数: 0
h-index: 0
机构:Duke Univ, Med Ctr, Dept Med, Howard Hughes Med Inst, Durham, NC 27710 USA
Shenolikar, S
Weinman, EJ
论文数: 0引用数: 0
h-index: 0
机构:Duke Univ, Med Ctr, Dept Med, Howard Hughes Med Inst, Durham, NC 27710 USA
Weinman, EJ
Grinstein, S
论文数: 0引用数: 0
h-index: 0
机构:Duke Univ, Med Ctr, Dept Med, Howard Hughes Med Inst, Durham, NC 27710 USA
Grinstein, S
Lefkowitz, RJ
论文数: 0引用数: 0
h-index: 0
机构:
Duke Univ, Med Ctr, Dept Med, Howard Hughes Med Inst, Durham, NC 27710 USADuke Univ, Med Ctr, Dept Med, Howard Hughes Med Inst, Durham, NC 27710 USA