Apoptosis in the anucleate platelet

被引：174

作者：

Leytin, Valery ^{[1
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,4
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机构：

[1] St Michaels Hosp, Div Transfus Med, Dept Lab Med, Keenan Res Ctr,Li Ka Shing Knowledge Inst, Toronto, ON M5B 1W8, Canada

[2] Toronto Platelet Immunobiol Grp, Toronto, ON, Canada

[3] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada

[4] Univ Toronto, Dept Med, Toronto, ON, Canada

来源：

BLOOD REVIEWS | 2012年 / 26卷 / 02期

关键词：

Platelet apoptosis; Extrinsic and intrinsic apoptosis pathways; Apoptosis triggers and markers; PAR-1; GPIIbIIIa; GPIb alpha receptors; Mitochodrial control; Shear stress; Cyclosporin A; Intravenous immunoglobulin; Eptifibatide (Integrilin); Tirofiban (Aggrastat); MITOCHONDRIAL PERMEABILITY TRANSITION; IMMUNE THROMBOCYTOPENIC PURPURA; INTRAVENOUS IMMUNOGLOBULIN; INDUCE APOPTOSIS; CELL-DEATH; PHOSPHATIDYLSERINE EXPOSURE; PROTEIN-SYNTHESIS; ACTIVATED PLATELETS; CASPASE ACTIVATION; BH3-ONLY PROTEINS;

D O I：

10.1016/j.blre.2011.10.002

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

For many years, programmed cell death, known as apoptosis, was attributed exclusively to nucleated cells. Currently, however, apoptosis is also well-documented in anucleate platelets. This review describes extrinsic and intrinsic pathways of apoptosis in nucleated cells and in platelets, platelet apoptosis induced by multiple chemical stimuli and shear stresses, markers of platelet apoptosis, mitochodrial control of platelet apoptosis, and apoptosis mediated by platelet surface receptors PAR-1, GPIIbIIIa and GPIb alpha. In addition, this review presents data on platelet apoptosis provoked by aging of platelets in vitro during platelet storage, platelet apoptosis in pathological settings in humans and animal models, and inhibition of platelet apoptosis by cyclosporin A, intravenous immunoglobulin and GPIIbIIIa antagonist drugs. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：51 / 63

页数：13

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