Allosteric inhibition of fructose-1,6-bisphosphatase by anilinoquinazolines

被引：38

作者：

Wright, SW

Hageman, DL

McClure, LD

Carlo, AA

Treadway, JL

Mathiowetz, AM

Withka, JM

Bauer, PH

机构：

[1] Pfizer Inc, Cent Res, Groton, CT 06340 USA

[2] Pfizer Discovery Technol Ctr, Cambridge, MA 02139 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(00)00586-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Anilinoquinazolines currently of interest as inhibitors of tyrosine kinases have been found to be allosteric inhibitors of the enzyme fructose 1,6-bisphosphatase. These represent a new approach to inhibition of F16BPase and serve as leads for further drug design. Enzyme inhibition is achieved by binding at an unidentified allosteric site. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：17 / 21

页数：5

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