Mutagenesis - Purposeful mutations

被引：13

作者：

Goodman, MF ^{[1
]}

机构：

[1] Univ So Calif, Dept Biol, Program Mol Biol, Los Angeles, CA 90089 USA

来源：

NATURE | 1998年 / 395卷 / 6699期

关键词：

D O I：

10.1038/26111

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

When DNA is damaged, repair systems exist to remove lesions and fill in gaps. So when that DNA is replicated, the original sequence will be passed on to daughter cells. ButEscherichia colicontains proteins that do just the opposite -- they reduce replication fidelity. The study of these proteins should now be easier, thanks to in vitrosystems developed by two groups, that reconstitute this so-called error-prone repair.

引用

页码：221 / +

页数：2

共 14 条

[1] NEW RECA MUTATIONS THAT DISSOCIATE THE VARIOUS RECA PROTEIN ACTIVITIES IN ESCHERICHIA-COLI PROVIDE EVIDENCE FOR AN ADDITIONAL ROLE FOR RECA PROTEIN IN UV MUTAGENESIS
DUTREIX, M
MOREAU, PL
BAILONE, A
GALIBERT, F
BATTISTA, JR
WALKER, GC
DEVORET, R
[J]. JOURNAL OF BACTERIOLOGY, 1989, 171 (05) : 2415 - 2423
[2] ECHOLS H, 1991, ANNU REV BIOCHEM, V60, P477, DOI 10.1146/annurev.biochem.60.1.477
[3] Enhancement of DNA repair in human skin cells by thymidine dinucleotides: Evidence for a p53-mediated mammalian SOS response
Eller, MS
Maeda, T
Magnoni, C
Atwal, D
Gilchrest, BA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (23) : 12627 - 12632
[4] Friedberg E., 1995, DNA REPAIR MUTAGENES, P407
[5] ACCURACY OF REPLICATION PAST THE T-C (6-4) ADDUCT
HORSFALL, MJ
LAWRENCE, CW
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1994, 235 (02) : 465 - 471
[6] MUTATION FREQUENCY AND SPECTRUM RESULTING FROM A SINGLE ABASIC SITE IN A SINGLE-STRANDED VECTOR
LAWRENCE, CW
BORDEN, A
BANERJEE, SK
LECLERC, JE
[J]. NUCLEIC ACIDS RESEARCH, 1990, 18 (08) : 2153 - 2157
[7] Arrested DNA replication in Xenopus and release by Escherichia coli mutagenesis proteins
Oda, N
Levin, JD
Spoonde, AY
Frank, EG
Levine, AS
Woodgate, R
Ackerman, EJ
[J]. SCIENCE, 1996, 272 (5268) : 1644 - 1646
[8] PETIT MA, 1994, J BIOL CHEM, V269, P23824
[9] ACTIVITY OF THE PURIFIED MUTAGENESIS PROTEINS UMUC, UMUD', AND RECA IN REPLICATIVE BYPASS OF AN ABASIC DNA LESION BY DNA POLYMERASE-III
RAJAGOPALAN, M
LU, C
WOODGATE, R
ODONNELL, M
GOODMAN, MF
ECHOLS, H
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (22) : 10777 - 10781
[10] The mutagenesis proteins UmuD′ and UmuC prevent lethal frameshifts while increasing base substitution mutations
Reuven, NB
Tomer, G
Livneh, Z
[J]. MOLECULAR CELL, 1998, 2 (02) : 191 - 199

← 1 2 →