Contact-Active Antimicrobial and Potentially Self-Polishing Coatings Based on Cellulose

被引：48

作者：

Bieser, Arno M. ^{[2
,3
]}

Thomann, Yi ^{[2
,3
]}

Tiller, Joerg C. ^{[1
]}

机构：

[1] TU Dortmund, Dept Bio & Chem Engn, D-44227 Dortmund, Germany

[2] Univ Freiburg, Freiburg Mat Res Ctr, D-79104 Freiburg, Germany

[3] Univ Freiburg, Inst Macromol Chem, Dept Chem, D-79104 Freiburg, Germany

来源：

MACROMOLECULAR BIOSCIENCE | 2011年 / 11卷 / 01期

关键词：

antimicrobial; biodegradable; contact-active; polyoxazoline; self-polishing; SATELLITE GROUPS; POLYMER SURFACE; DERIVATIVES; BACTERIA; DESIGN; OXIDE;

D O I：

10.1002/mabi.201000306

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A contact-active antimicrobial coating is described that is only degraded in the presence of cellulase, which is an extracellular enzyme of numerous microbial strains. Antimicrobial DDA was grafted to a cellulose backbone via a polymeric spacer. The antimicrobial activity of the coatings, their biodegradability and their self-polishing potential were investigated. It was found that all coatings were antimicrobially active against Staphylococcus aureus. Coatings with high DS and long polymeric spacers degraded in water, while coatings with low DS and short spacers were not hydrolyzed even in the presence of cellulase. One coating was found to be selectively degradable by cellulase and recovered most of its antimicrobial activity after overloading and subsequent treatment with cellulase.

引用

页码：111 / 121

页数：11

共 48 条

[1] A NEW PROCEDURE FOR THE DETERMINATION OF THE FINE STRUCTURE OF POLYSACCHARIDES [J].

ABDELAKHER, M ;

HAMILTON, JK ;

MONTGOMERY, R ;

SMITH, F .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1952, 74 (19) :4970-4971

[2] Iron and infection: the heart of the matter [J].

Bullen, JJ ;

Rogers, HJ ;

Spalding, PB ;

Ward, CG .

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 2005, 43 (03) :325-330

[3] A Switchable Biocompatible Polymer Surface with Self-Sterilizing and Nonfouling Capabilities [J].

Cheng, Gang ;

Xite, Hong ;

Zhang, Zheng ;

Chen, Shengfu ;

Jiang, Shaoyi .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2008, 47 (46) :8831-8834

[4] THE CATIONIC GRAFTING OF CELLULOSE WITH 2-METHYL-2-OXAZOLINE [J].

CHERADAME, H ;

UPE, TA ;

GANDINI, A .

MAKROMOLEKULARE CHEMIE-MACROMOLECULAR SYMPOSIA, 1986, 6 :261-270

[5]

Daly W. H., 2006, POLYM PREPR, V47, P121

[6] SURFACE-IMMOBILIZED POLYETHYLENE OXIDE FOR BACTERIAL REPELLENCE [J].

DESAI, NP ;

HOSSAINY, SFA ;

HUBBELL, JA .

BIOMATERIALS, 1992, 13 (07) :417-420

[7] BIOSOLUBLE SURGICAL MATERIAL FROM 2,3-DIALDEHYDE CELLULOSE [J].

DEVI, KS ;

SINHA, TJM ;

VASUDEVAN, P .

BIOMATERIALS, 1986, 7 (03) :193-196

[8] Contact-active antimicrobial coatings derived from aqueous suspensions [J].

Fuchs, Andreas D. ;

Tiller, Joerg C. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (40) :6759-6762

[9] Reducing implant-related infections: active release strategies [J].

Hetrick, Evan M. ;

Schoenfisch, Mark H. .

CHEMICAL SOCIETY REVIEWS, 2006, 35 (09) :780-789

[10] Screening and Characterization of Surface-Tethered Cationic Peptides for Antimicrobial Activity [J].

Hilpert, Kai ;

Elliott, Melissa ;

Jenssen, Havard ;

Kindrachuk, Jason ;

Fjell, Christopher D. ;

Koerner, Jana ;

Winkler, Dirk F. H. ;

Weaver, Lindsay L. ;

Henklein, Peter ;

Ulrich, Anne S. ;

Chiang, Sandy H. Y. ;

Farmer, Susan W. ;

Pante, Nelly ;

Volkmer, Rudolf ;

Hancock, Robert E. W. .

CHEMISTRY & BIOLOGY, 2009, 16 (01) :58-69

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