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Mammalian telomeres and telomerase: why they matter for cancer and aging

被引：80
作者：
Blasco, MA [1 ]
机构：
[1] Natl Biotechnol Ctr, Dept Immunol & Oncol, Madrid, Spain
来源：
EUROPEAN JOURNAL OF CELL BIOLOGY | 2003年 / 82卷 / 09期
关键词：
telomeres; telomerase; mouse models; cancer; aging; DNA repair;
D O I：
10.1078/0171-9335-00335
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Chromosome ends, or telomeres, are formed by a special chromatin structure that protects them from recombination and degradation, thus preventing end-to-end chromosome fusions and other chromosomal aberrations. The functionality of telomeres, and that of the cellular activity that synthesizes them, telomerase, has been shown to impact on both cancer and aging, as well as on the organismal sensitivity to ionizing radiation. This review focuses on the analysis of different mouse models for proteins that are important for telomere function, which have highlighted the importance of telomeres and telomerase for cancer and aging.
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收藏
页码：441 / 446
页数：6
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