A MAP for Bundling Microtubules

被引：65

作者：

Walczak, Claire E. ^{[1
]}

Shaw, Sidney L. ^{[1
]}

机构：

[1] Indiana Univ, Dept Biol, Bloomington, IN 47405 USA

来源：

CELL | 2010年 / 142卷 / 03期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

SPINDLE MIDZONE; PRC1; ORGANIZATION; ARRAYS; MOTORS;

D O I：

10.1016/j.cell.2010.07.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Microtubules assemble into arrays of bundled filaments that are critical for multiple steps in cell division, including anaphase and cytokinesis. Recent structural and functional studies, including two papers in this issue of Cell (Bieling et al., 2010; Subramanian et al., 2010), demonstrate how the MAP65 protein PRC1 crosslinks microtubules and cooperates with kinesin motors to control the dynamics and size of bundled regions.

引用

收藏

页码：364 / 367

页数：4

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