The pathogenesis and diagnosis of foot-and-mouth disease

被引:657
作者
Alexandersen, S [1 ]
Zhang, Z [1 ]
Donaldson, AI [1 ]
Garland, AJM [1 ]
机构
[1] Inst Anim Hlth, Pirbright Lab, Woking GU24 ONF, Surrey, England
基金
英国生物技术与生命科学研究理事会;
关键词
cattle; FMD diagnosis; FMD pathogenesis; FMD virus excretion; FMD virus persistence; foot-and-mouth disease; pig; review article; sheep; viral infection;
D O I
10.1016/S0021-9975(03)00041-0
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
The pathogenesis of foot-and-mouth disease (FMD) is reviewed, taking account of knowledge gained from field and experimental studies and embracing investigations at the level of the virus, the cell, the organ, the whole animal and the herd or flock. The review also addresses the immune response and the carrier state in FMD. Progress made in understanding the pathogenesis of the disease is highlighted in relation to developments in diagnosis and methods of control. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:1 / 36
页数:36
相关论文
共 229 条
[1]   Experimental studies with foot-and-mouth disease virus, strain O, responsible for the 2001 epidemic in the United Kingdom [J].
Aggarwal, N ;
Zhang, Z ;
Cox, S ;
Statham, R ;
Alexandersen, S ;
Kitching, RP ;
Barnett, PV .
VACCINE, 2002, 20 (19-20) :2508-2515
[2]   Clinical and laboratory investigations of five outbreaks of foot-and-mouth disease during the 2001 epidemic in the United Kingdom [J].
Alexandersen, S ;
Kitching, RP ;
Mansley, LM ;
Donaldson, AI .
VETERINARY RECORD, 2003, 152 (16) :489-496
[3]   Quantities of infectious virus and viral RNA recovered from sheep and cattle experimentally infected with foot-and-mouth disease virus O UK 2001 [J].
Alexandersen, S ;
Zhang, Z ;
Reid, SM ;
Hutchings, GH ;
Donaldson, AI .
JOURNAL OF GENERAL VIROLOGY, 2002, 83 :1915-1923
[4]   Natural aerosol transmission of foot-and-mouth disease virus to pigs:: minimal infectious dose for strain O1 Lausanne [J].
Alexandersen, S ;
Brotherhood, I ;
Donaldson, AI .
EPIDEMIOLOGY AND INFECTION, 2002, 128 (02) :301-312
[5]   Further studies to quantify the dose of natural aerosols of foot-and-mouth disease virus for pigs [J].
Alexandersen, S ;
Donaldson, AI .
EPIDEMIOLOGY AND INFECTION, 2002, 128 (02) :313-323
[6]   The early pathogenesis of foot-and-mouth disease in pigs infected by contact: a quantitative time-course study using TaqMan RT-PCR [J].
Alexandersen, S ;
Oleksiewicz, MB ;
Donaldson, AI .
JOURNAL OF GENERAL VIROLOGY, 2001, 82 :747-755
[7]   Development of reverse transcription-PCR (oligonucleotide probing) enzyme-linked immunosorbent assays for diagnosis and preliminary typing of foot-and-mouth disease: A new system using simple and aqueous-phase hybridization [J].
Alexandersen, S ;
Forsyth, MA ;
Reid, SM ;
Belsham, GJ .
JOURNAL OF CLINICAL MICROBIOLOGY, 2000, 38 (12) :4604-4613
[8]   Aspects of the persistence of foot-and-mouth disease virus in animals - the carrier problem [J].
Alexandersen, S ;
Zhang, ZD ;
Donaldson, AI .
MICROBES AND INFECTION, 2002, 4 (10) :1099-1110
[9]  
ALEXANDERSEN S, 2003, IN PRESS J COMP PATH
[10]   HUMORAL AND CELLULAR-PARAMETERS OF EXPERIMENTAL FOOT-AND-MOUTH-DISEASE IN HEIFERS [J].
AMADORI, M ;
MELEGARI, M .
JOURNAL OF VETERINARY MEDICINE SERIES B-ZENTRALBLATT FUR VETERINARMEDIZIN REIHE B-INFECTIOUS DISEASES AND VETERINARY PUBLIC HEALTH, 1987, 34 (07) :480-488