Synthesis and in vitro antitumor activity of 4(3H)-quinazolinone derivatives with dithiocarbamate side chains

被引：367

作者：

Cao, SL ^{[1
]}

Feng, YP

Jiang, YY

Liu, SY

Ding, GY

Li, RT

机构：

[1] Capital Normal Univ, Dept Chem, Beijing 100037, Peoples R China

[2] Tsing Hua Univ, Dept Chem, Beijing 100084, Peoples R China

[3] Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 07期

关键词：

4(3H)-quinazolinone; dithiocarbamate; antitumor activity; K562; cells;

D O I：

10.1016/j.bmcl.2005.01.083

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 4(3H)-quinazolinone derivatives with dithiocarbamate side chains were synthesized and tested for their in vitro antitumor activity against human myelogenous leukemia K562 cells. Among them, (3,4-dihydro-2-methyl-4-oxoquinazolin-6-yl)methyl 4-(4-fluorophenyl)piperazine-1-carbodithioate 8q exhibited significant inhibitory activity against K562 cells with IC50 value of 0.5 mu M. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1915 / 1917

页数：3

共 13 条

[11] CANCER CHEMOPREVENTIVE ACTIVITY OF BRASSININ, A PHYTOALEXIN FROM CABBAGE
MEHTA, RG
LIU, JF
CONSTANTINOU, A
THOMAS, CF
HAWTHORNE, M
YOU, M
GERHAUSER, C
PEZZUTO, JM
MOON, RC
MORIARTY, RM
[J]. CARCINOGENESIS, 1995, 16 (02) : 399 - 404
[12] Apoptosis induced by (DIPP-L-Leu)2-L-Lys-OCH3 in K562 cells
Niu, YL
Jiang, YY
Cao, SL
Du, W
Zhao, YF
[J]. CHINESE SCIENCE BULLETIN, 2003, 48 (09): : 869 - 872
[13] AG337, a novel lipophilic thymidylate synthase inhibitor: In vitro and in vivo preclinical studies
Webber, S
Bartlett, CA
Boritzki, TJ
Hilliard, JA
Howland, EF
Johnston, AL
Kosa, M
Margosiak, SA
Morse, CA
Shetty, BV
[J]. CANCER CHEMOTHERAPY AND PHARMACOLOGY, 1996, 37 (06) : 509 - 517

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