Global dynamics of an SEIR epidemic model with saturating contact rate

Heesterbeek and Metz [J. Math. Biol. 31 (1993) 529] derived an expression for the saturating contact rate of individual contacts in an epidemiological model. In this paper, the SEIR model with this saturating contact rate is studied. The basic reproduction number R-0 is proved to be a sharp threshold which completely determines the global dynamics and the outcome of the disease. If R-0 less than or equal to 1, the disease-free equilibrium is globally stable and the disease always dies out. If R-0 > 1, there exists a unique endemic equilibrium which is globally stable and the disease persists at an endemic equilibrium state if it initially exists. The contribution of the saturating contact rate to the basic reproduction number and the level of the endemic equilibrium is also analyzed. (C) 2003 Elsevier Inc. All rights reserved.