Validation of Genome-Wide Prostate Cancer Associations in Men of African Descent

被引：75

作者：

Chang, Bao-Li ^{[1
]}

Spangler, Elaine ^{[1
]}

Gallagher, Stephen ^{[1
]}

Haiman, Christopher A. ^{[2
,3
]}

Henderson, Brian ^{[2
,3
]}

Isaacs, William ^{[4
,5
]}

Benford, Marnita L. ^{[6
]}

Kidd, LaCreis R. ^{[6
]}

Cooney, Kathleen ^{[7
]}

Strom, Sara ^{[8
]}

Ingles, Sue Ann ^{[9
]}

Stern, Mariana C. ^{[9
]}

Corral, Roman ^{[9
]}

Joshi, Amit D. ^{[9
]}

Xu, Jianfeng ^{[10
]}

Giri, Veda N. ^{[11
]}

Rybicki, Benjamin ^{[12
]}

Neslund-Dudas, Christine ^{[12
]}

Kibel, Adam S. ^{[13
]}

Thompson, Ian M. ^{[14
,15
]}

Leach, Robin J. ^{[14
,15
]}

Ostrander, Elaine A. ^{[16
]}

Stanford, Janet L. ^{[17
]}

Witte, John ^{[18
,19
]}

Casey, Graham ^{[9
]}

Eeles, Rosalind ^{[20
,21
]}

Hsing, Ann W. ^{[22
]}

Chanock, Stephen ^{[22
]}

Hu, Jennifer J. ^{[24
]}

John, Esther M. ^{[23
]}

Park, Jong ^{[25
]}

Stefflova, Klara ^{[1
]}

Zeigler-Johnson, Charnita ^{[1
]}

Rebbeck, Timothy R. ^{[1
,26
]}

机构：

[1] Univ Penn, Sch Med, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA

[2] Univ So Calif, Dept Prevent Med, Los Angeles, CA 90089 USA

[3] Univ So Calif, Kenneth Norris Jr Comprehens Canc Ctr, Los Angeles, CA 90033 USA

[4] Johns Hopkins Univ, Sch Med, Baltimore, MD USA

[5] Bloomberg Sch Publ Hlth, Baltimore, MD USA

[6] Univ Louisville, Louisville, KY 40292 USA

[7] Univ Michigan, Med Ctr, Dept Med, Ann Arbor, MI 48109 USA

[8] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[9] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA

[10] Wake Forest Univ, Winston Salem, NC 27109 USA

[11] Fox Chase Canc Ctr, Philadelphia, PA 19111 USA

[12] Henry Ford Hosp, Detroit, MI 48202 USA

[13] Washington Univ, Sch Med, Dept Surg & Genet, St Louis, MO USA

[14] Univ Texas Hlth Sci Ctr San Antonio, Dept Urol, San Antonio, TX USA

[15] Univ Texas Hlth Sci Ctr San Antonio, Canc Therapy & Res Ctr, San Antonio, TX USA

[16] NHGRI, Bethesda, MD 20892 USA

[17] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA

[18] Univ Calif San Francisco, Dept Epidemiol & Biostat, Inst Human Genet, San Francisco, CA 94143 USA

[19] Univ Calif San Francisco, Dept Urol, Inst Human Genet, San Francisco, CA 94143 USA

[20] Inst Canc Res, Sutton, Surrey, England

[21] Royal Marsden NHS Trust, Sutton, Surrey, England

[22] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

[23] No Calif Canc Ctr, Union City, CA USA

[24] Univ Miami, Miller Sch Med, Miami, FL 33136 USA

[25] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL USA

[26] Univ Penn, Sch Med, Abramson Canc Ctr, Philadelphia, PA 19104 USA

来源：

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | 2011年 / 20卷 / 01期

基金：

美国国家卫生研究院;

关键词：

RISK-ASSOCIATED LOCI; ENDOMETRIAL STROMAL SARCOMA; 94; AMINO-ACIDS; SEQUENCE VARIANTS; AMERICAN MEN; SUSCEPTIBILITY LOCUS; FUNCTIONAL-ANALYSIS; SECRETORY PROTEIN; COMMON VARIANT; MULTIPLE LOCI;

D O I：

10.1158/1055-9965.EPI-10-0698

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Genome-wide association studies (GWAS) have identified numerous prostate cancer susceptibility alleles, but these loci have been identified primarily in men of European descent. There is limited information about the role of these loci in men of African descent. Methods: We identified 7,788 prostate cancer cases and controls with genotype data for 47 GWAS-identified loci. Results: We identified significant associations for SNP rs10486567 at JAZF1, rs10993994 at MSMB, rs12418451 and rs7931342 at 11q13, and rs5945572 and rs5945619 at NUDT10/11. These associations were in the same direction and of similar magnitude as those reported in men of European descent. Significance was attained at all reported prostate cancer susceptibility regions at chromosome 8q24, including associations reaching genome-wide significance in region 2. Conclusion: We have validated in men of African descent the associations at some, but not all, prostate cancer susceptibility loci originally identified in European descent populations. This may be due to the heterogeneity in genetic etiology or in the pattern of genetic variation across populations. Impact: The genetic etiology of prostate cancer in men of African descent differs from that of men of European descent. Cancer Epidemiol Biomarkers Prev; 20(1); 23-32. (C) 2011 AACR.

引用

页码：23 / 32

页数：10

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