Multiple loci on 8q24 associated with prostate cancer susceptibility

被引：230

作者：

Al Olama, Ali Amin ^{[1
]}

Kote-Jarai, Zsofia ^{[2
]}

Giles, Graham G. ^{[3
,4
]}

Guy, Michelle ^{[2
]}

Morrison, Jonathan ^{[1
]}

Severi, Gianluca ^{[3
,4
]}

Leongamornlert, Daniel A. ^{[2
]}

Tymrakiewicz, Malgorzata ^{[2
]}

Jhavar, Sameer ^{[2
]}

Saunders, Ed ^{[2
]}

Hopper, John L. ^{[4
]}

Southey, Melissa C. ^{[5
]}

Muir, Kenneth R. ^{[6
]}

English, Dallas R. ^{[4
]}

Dearnaley, David P. ^{[2
,7
]}

Ardern-Jones, Audrey T. ^{[7
]}

Hall, Amanda L. ^{[2
,7
]}

O'Brien, Lynne T. ^{[2
]}

Wilkinson, Rosemary A. ^{[2
]}

Sawyer, Emma ^{[2
]}

Lophatananon, Artitaya ^{[6
]}

Horwich, Alan ^{[2
,7
]}

Huddart, Robert A. ^{[2
,7
]}

Khoo, Vincent S. ^{[2
,7
]}

Parker, Christopher C. ^{[2
,7
]}

Woodhouse, Christopher J. ^{[7
]}

Thompson, Alan ^{[7
]}

Christmas, Tim ^{[7
]}

Ogden, Chris ^{[7
]}

Cooper, Colin ^{[2
]}

Donovan, Jenny L. ^{[8
]}

Hamdy, Freddie C. ^{[9
]}

Neal, David E. ^{[7
,10
,11
,12
]}

Eeles, Rosalind A. ^{[2
]}

Easton, Douglas F. ^{[1
]}

机构：

[1] Univ Cambridge, Canc Res UK Genet Epidemiol Unit, Cambridge, England

[2] Inst Canc Res, Surrey, England

[3] Canc Council Victoria, Canc Epidemiol Ctr, Carlton, Vic, Australia

[4] Univ Melbourne, Ctr Mol Environm Genet & Analyt Epidemiol, Carlton, Vic 3053, Australia

[5] Univ Melbourne, Dept Pathol, Genet Epidemiol Lab, Parkville, Vic 3052, Australia

[6] Univ Nottingham, Sch Med, Queens Med Ctr, Nottingham, England

[7] Royal Marsden Natl Hlth Serv Fdn Trust, Surrey, England

[8] Univ Bristol, Dept Social Med, Bristol, Avon, England

[9] Univ Oxford, Nuffield Dept Surg, Oxford, England

[10] Li Ka Shing Ctr, Canc Res UK Cambridge Res Inst, Cambridge, England

[11] Univ Cambridge, Addenbrookes Hosp, Dept Oncol, Cambridge CB2 2QQ, England

[12] Univ Cambridge, Addenbrookes Hosp, Dept Surg, Cambridge CB2 2QQ, England

来源：

NATURE GENETICS | 2009年 / 41卷 / 10期

基金：

英国医学研究理事会;

关键词：

GENOME-WIDE ASSOCIATION; RISK LOCUS; COLORECTAL-CANCER; RS6983267; AMERICANS; VARIANTS; MYC;

D O I：

10.1038/ng.452

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Previous studies have identified multiple loci on 8q24 associated with prostate cancer risk. We performed a comprehensive analysis of SNP associations across 8q24 by genotyping tag SNPs in 5,504 prostate cancer cases and 5,834 controls. We confirmed associations at three previously reported loci and identified additional loci in two other linkage disequilibrium blocks (rs1006908: per-allele OR = 0.87, P = 7.9 x 10(-8); rs620861: OR = 0.90, P = 4.8 x 10(-8)). Eight SNPs in five linkage disequilibrium blocks were independently associated with prostate cancer susceptibility.

引用

页码：1058 / 1060

页数：3

共 15 条

[1] A common variant associated with prostate cancer in European and African populations [J].

Amundadottir, Laufey T. ;

Sulem, Patrick ;

Gudmundsson, Julius ;

Helgason, Agnar ;

Baker, Adam ;

Agnarsson, Bjarni A. ;

Sigurdsson, Asgeir ;

Benediktsdottir, Kristrun R. ;

Cazier, Jean-Baptiste ;

Sainz, Jesus ;

Jakobsdottir, Margret ;

Kostic, Jelena ;

Magnusdottir, Droplaug N. ;

Ghosh, Shyamali ;

Agnarsson, Kari ;

Birgisdottir, Birgitta ;

Le Roux, Louise ;

Olafsdottir, Adalheidur ;

Blondal, Thorarinn ;

Andresdottir, Margret ;

Gretarsdottir, Olafia Svandis ;

Bergthorsson, Jon T. ;

Gudbjartsson, Daniel ;

Gylfason, Arnaldur ;

Thorleifsson, Gudmar ;

Manolescu, Andrei ;

Kristjansson, Kristleifur ;

Geirsson, Gudmundur ;

Isaksson, Helgi ;

Douglas, Julie ;

Johansson, Jan-Erik ;

Balter, Katarina ;

Wiklund, Fredrik ;

Montie, James E. ;

Yu, Xiaoying ;

Suarez, Brian K. ;

Ober, Carole ;

Cooney, Kathleen A. ;

Gronberg, Henrik ;

Catalona, William J. ;

Einarsson, Gudmundur V. ;

Barkardottir, Rosa B. ;

Gulcher, Jeffrey R. ;

Kong, Augustine ;

Thorsteinsdottir, Unnur ;

Stefansson, Kari .

NATURE GENETICS, 2006, 38 (06) :652-658

[2] Genome-wide association study identifies novel breast cancer susceptibility loci [J].

Easton, Douglas F. ;

Pooley, Karen A. ;

Dunning, Alison M. ;

Pharoah, Paul D. P. ;

Thompson, Deborah ;

Ballinger, Dennis G. ;

Struewing, Jeffery P. ;

Morrison, Jonathan ;

Field, Helen ;

Luben, Robert ;

Wareham, Nicholas ;

Ahmed, Shahana ;

Healey, Catherine S. ;

Bowman, Richard ;

Meyer, Kerstin B. ;

Haiman, Christopher A. ;

Kolonel, Laurence K. ;

Henderson, Brian E. ;

Le Marchand, Loic ;

Brennan, Paul ;

Sangrajrang, Suleeporn ;

Gaborieau, Valerie ;

Odefrey, Fabrice ;

Shen, Chen-Yang ;

Wu, Pei-Ei ;

Wang, Hui-Chun ;

Eccles, Diana ;

Evans, D. Gareth ;

Peto, Julian ;

Fletcher, Olivia ;

Johnson, Nichola ;

Seal, Sheila ;

Stratton, Michael R. ;

Rahman, Nazneen ;

Chenevix-Trench, Georgia ;

Bojesen, Stig E. ;

Nordestgaard, Borge G. ;

Axelsson, Christen K. ;

Garcia-Closas, Montserrat ;

Brinton, Louise ;

Chanock, Stephen ;

Lissowska, Jolanta ;

Peplonska, Beata ;

Nevanlinna, Heli ;

Fagerholm, Rainer ;

Eerola, Hannaleena ;

Kang, Daehee ;

Yoo, Keun-Young ;

Noh, Dong-Young ;

Ahn, Sei-Hyun .

NATURE, 2007, 447 (7148) :1087-U7

[3] Multiple newly identified loci associated with prostate cancer susceptibility [J].

Eeles, Rosalind A. ;

Kote-Jarai, Zsofia ;

Giles, Graham G. ;

Al Olama, Ali Amin ;

Guy, Michelle ;

Jugurnauth, Sarah K. ;

Mulholland, Shani ;

Leongamornlert, Daniel A. ;

Edwards, Stephen M. ;

Morrison, Jonathan ;

Field, Helen I. ;

Southey, Melissa C. ;

Severi, Gianluca ;

Donovan, Jenny L. ;

Hamdy, Freddie C. ;

Dearnaley, David P. ;

Muir, Kenneth R. ;

Smith, Charmaine ;

Bagnato, Melisa ;

Ardern-Jones, Audrey T. ;

Hall, Amanda L. ;

O'Brien, Lynne T. ;

Gehr-Swain, Beatrice N. ;

Wilkinson, Rosemary A. ;

Cox, Angie ;

Lewis, Sarah ;

Brown, Paul M. ;

Jhavar, Sameer G. ;

Tymrakiewicz, Malgorzata ;

Lophatananon, Artitaya ;

Bryant, Sarah L. ;

Horwich, Alan ;

Huddart, Robert A. ;

Khoo, Vincent S. ;

Parker, Christopher C. ;

Woodhouse, Christopher J. ;

Thompson, Alan ;

Christmas, Tim ;

Ogden, Chris ;

Fisher, Cyril ;

Jamieson, Charles ;

Cooper, Colin S. ;

English, Dallas R. ;

Hopper, John L. ;

Neal, David E. ;

Easton, Douglas F. .

NATURE GENETICS, 2008, 40 (03) :316-321

[4] Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men [J].

Freedman, Matthew L. ;

Haiman, Christopher A. ;

Patterson, Nick ;

McDonald, Gavin J. ;

Tandon, Arti ;

Waliszewska, Alicja ;

Penney, Kathryn ;

Steen, Robert G. ;

Ardlie, Kristin ;

John, Esther M. ;

Clakley-Girvan, Ingrid ;

Whitternore, Alice S. ;

Cooney, Kathleen A. ;

Ingles, Sue A. ;

Altshuler, David ;

Henderson, Brian E. ;

Reich, David .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (38) :14068-14073

[5] Multiple loci with different cancer specificities within the 8q24 gene desert [J].

Ghoussaini, Maya ;

Song, Honglin ;

Koessler, Thibaud ;

Al Olama, Ali Amin ;

Kote-Jarai, Zsofia ;

Driver, Kristy E. ;

Pooley, Karen A. ;

Ramus, Susan J. ;

Kjaer, Susanne Krueger ;

Hogdall, Estrid ;

DiCioccio, Richard A. ;

Whittemore, Alice S. ;

Gayther, Simon A. ;

Giles, Graham G. ;

Guy, Michelle ;

Edwards, Stephen M. ;

Morrison, Jonathan ;

Donovan, Jenny L. ;

Hamdy, Freddie C. ;

Dearnaley, David P. ;

Ardern-Jones, Audrey T. ;

Hall, Amanda L. ;

O'Brien, Lynne T. ;

Gehr-Swain, Beatrice N. ;

Wilkinson, Rosemary A. ;

Brown, Paul M. ;

Hopper, John L. ;

Neal, David E. ;

Pharoah, Paul D. P. ;

Ponder, Bruce A. J. ;

Eeles, Rosalind A. ;

Easton, Douglas F. ;

Dunning, Alison M. .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2008, 100 (13) :962-966

[6] Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24 [J].

Gudmundsson, Julius ;

Sulem, Patrick ;

Manolescu, Andrei ;

Amundadottir, Laufey T. ;

Gudbjartsson, Daniel ;

Helgason, Agnar ;

Rafnar, Thorunn ;

Bergthorsson, Jon T. ;

Agnarsson, Bjarni A. ;

Baker, Adam ;

Sigurdsson, Asgeir ;

Benediktsdottir, Kristrun R. ;

Jakobsdottir, Margret ;

Xu, Jianfeng ;

Blondal, Thorarinn ;

Kostic, Jelena ;

Sun, Jielin ;

Ghosh, Shyamali ;

Stacey, Simon N. ;

Mouy, Magali ;

Saemundsdottir, Jona ;

Backman, Valgerdur M. ;

Kristjansson, Kristleifur ;

Tres, Alejandro ;

Partin, Alan W. ;

Albers-Akkers, Marjo T. ;

Marcos, Javier Godino-Ivan ;

Walsh, Patrick C. ;

Swinkels, Dorine W. ;

Navarrete, Sebastian ;

Isaacs, Sarah D. ;

Aben, Katja K. ;

Graif, Theresa ;

Cashy, John ;

Ruiz-Echarri, Manuel ;

Wiley, Kathleen E. ;

Suarez, Brian K. ;

Witjes, J. Alfred ;

Frigge, Mike ;

Ober, Carole ;

Jonsson, Eirikur ;

Einarsson, Gudmundur V. ;

Mayordomo, Jose I. ;

Kiemeney, Lambertus A. ;

Isaacs, William B. ;

Catalona, William J. ;

Barkardottir, Rosa B. ;

Gulcher, Jeffrey R. ;

Thorsteinsdottir, Unnur ;

Kong, Augustine .

NATURE GENETICS, 2007, 39 (05) :631-637

[7] Multiple regions within 8q24 independently affect risk for prostate cancer [J].

Haiman, Christopher A. ;

Patterson, Nick ;

Freedman, Matthew L. ;

Myers, Simon R. ;

Pike, Malcolm C. ;

Waliszewska, Alicja ;

Neubauer, Julie ;

Tandon, Arti ;

Schirmer, Christine ;

McDonald, Gavin J. ;

Greenway, Steven C. ;

Stram, Daniel O. ;

Le Marchand, Loic ;

Kolonel, Laurence N. ;

Frasco, Melissa ;

Wong, David ;

Pooler, Loreall C. ;

Ardlie, Kristin ;

Oakley-Girvan, Ingrid ;

Whittemore, Alice S. ;

Cooney, Kathleen A. ;

John, Esther M. ;

Ingles, Sue A. ;

Altshuler, David ;

Henderson, Brian E. ;

Reich, David .

NATURE GENETICS, 2007, 39 (05) :638-644

[8] The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer [J].

Pomerantz, Mark M. ;

Ahmadiyeh, Nasim ;

Jia, Li ;

Herman, Paula ;

Verzi, Michael P. ;

Doddapaneni, Harshavardhan ;

Beckwith, Christine A. ;

Chan, Jennifer A. ;

Hills, Adam ;

Davis, Matt ;

Yao, Keluo ;

Kehoe, Sarah M. ;

Lenz, Heinz-Josef ;

Haiman, Christopher A. ;

Yan, Chunli ;

Henderson, Brian E. ;

Frenkel, Baruch ;

Barretina, Jordi ;

Bass, Adam ;

Tabernero, Josep ;

Baselga, Jose ;

Regan, Meredith M. ;

Manak, J. Robert ;

Shivdasani, Ramesh ;

Coetzee, Gerhard A. ;

Freedman, Matthew L. .

NATURE GENETICS, 2009, 41 (08) :882-884

[9] Evaluation of the 8q24 Prostate Cancer Risk Locus and MYC Expression [J].

Pomerantz, Mark M. ;

Beckwith, Christine A. ;

Regan, Meredith M. ;

Wyman, Stacia K. ;

Petrovics, Gyorgy ;

Chen, Yongmei ;

Hawksworth, Dorota J. ;

Schumacher, Fredrick R. ;

Mucci, Lorelei ;

Penney, Kathryn L. ;

Stampfer, Meir J. ;

Chan, Jennifer A. ;

Ardlie, Kristin G. ;

Fritz, Brian R. ;

Parkin, Rachael K. ;

Lin, Daniel W. ;

Dyke, Michelle ;

Herman, Paula ;

Lee, Steve ;

Oh, William K. ;

Kantoff, Philip W. ;

Tewari, Muneesh ;

McLeod, David G. ;

Srivastava, Shiv ;

Freedman, Matthew L. .

CANCER RESEARCH, 2009, 69 (13) :5568-5574

[10] Confirmation study of prostate cancer risk variants at 8q24 in African Americans identifies a novel risk locus [J].

Robbins, Christiane ;

Torres, Jada Benn ;

Hooker, Stanley ;

Bonilla, Carolina ;

Hernandez, Wenndy ;

Candreva, Angela ;

Ahaghotu, Chiledum ;

Kittles, Rick ;

Carpten, John .

GENOME RESEARCH, 2007, 17 (12) :1717-1722

← 1 2 →

共 15 条

[1] A common variant associated with prostate cancer in European and African populations [J].

Amundadottir, Laufey T. ;

Sulem, Patrick ;

Gudmundsson, Julius ;

Helgason, Agnar ;

Baker, Adam ;

Agnarsson, Bjarni A. ;

Sigurdsson, Asgeir ;

Benediktsdottir, Kristrun R. ;

Cazier, Jean-Baptiste ;

Sainz, Jesus ;

Jakobsdottir, Margret ;

Kostic, Jelena ;

Magnusdottir, Droplaug N. ;

Ghosh, Shyamali ;

Agnarsson, Kari ;

Birgisdottir, Birgitta ;

Le Roux, Louise ;

Olafsdottir, Adalheidur ;

Blondal, Thorarinn ;

Andresdottir, Margret ;

Gretarsdottir, Olafia Svandis ;

Bergthorsson, Jon T. ;

Gudbjartsson, Daniel ;

Gylfason, Arnaldur ;

Thorleifsson, Gudmar ;

Manolescu, Andrei ;

Kristjansson, Kristleifur ;

Geirsson, Gudmundur ;

Isaksson, Helgi ;

Douglas, Julie ;

Johansson, Jan-Erik ;

Balter, Katarina ;

Wiklund, Fredrik ;

Montie, James E. ;

Yu, Xiaoying ;

Suarez, Brian K. ;

Ober, Carole ;

Cooney, Kathleen A. ;

Gronberg, Henrik ;

Catalona, William J. ;

Einarsson, Gudmundur V. ;

Barkardottir, Rosa B. ;

Gulcher, Jeffrey R. ;

Kong, Augustine ;

Thorsteinsdottir, Unnur ;

Stefansson, Kari .

NATURE GENETICS, 2006, 38 (06) :652-658

[2] Genome-wide association study identifies novel breast cancer susceptibility loci [J].

Easton, Douglas F. ;

Pooley, Karen A. ;

Dunning, Alison M. ;

Pharoah, Paul D. P. ;

Thompson, Deborah ;

Ballinger, Dennis G. ;

Struewing, Jeffery P. ;

Morrison, Jonathan ;

Field, Helen ;

Luben, Robert ;

Wareham, Nicholas ;

Ahmed, Shahana ;

Healey, Catherine S. ;

Bowman, Richard ;

Meyer, Kerstin B. ;

Haiman, Christopher A. ;

Kolonel, Laurence K. ;

Henderson, Brian E. ;

Le Marchand, Loic ;

Brennan, Paul ;

Sangrajrang, Suleeporn ;

Gaborieau, Valerie ;

Odefrey, Fabrice ;

Shen, Chen-Yang ;

Wu, Pei-Ei ;

Wang, Hui-Chun ;

Eccles, Diana ;

Evans, D. Gareth ;

Peto, Julian ;

Fletcher, Olivia ;

Johnson, Nichola ;

Seal, Sheila ;

Stratton, Michael R. ;

Rahman, Nazneen ;

Chenevix-Trench, Georgia ;

Bojesen, Stig E. ;

Nordestgaard, Borge G. ;

Axelsson, Christen K. ;

Garcia-Closas, Montserrat ;

Brinton, Louise ;

Chanock, Stephen ;

Lissowska, Jolanta ;

Peplonska, Beata ;

Nevanlinna, Heli ;

Fagerholm, Rainer ;

Eerola, Hannaleena ;

Kang, Daehee ;

Yoo, Keun-Young ;

Noh, Dong-Young ;

Ahn, Sei-Hyun .

NATURE, 2007, 447 (7148) :1087-U7

[3] Multiple newly identified loci associated with prostate cancer susceptibility [J].

Eeles, Rosalind A. ;

Kote-Jarai, Zsofia ;

Giles, Graham G. ;

Al Olama, Ali Amin ;

Guy, Michelle ;

Jugurnauth, Sarah K. ;

Mulholland, Shani ;

Leongamornlert, Daniel A. ;

Edwards, Stephen M. ;

Morrison, Jonathan ;

Field, Helen I. ;

Southey, Melissa C. ;

Severi, Gianluca ;

Donovan, Jenny L. ;

Hamdy, Freddie C. ;

Dearnaley, David P. ;

Muir, Kenneth R. ;

Smith, Charmaine ;

Bagnato, Melisa ;

Ardern-Jones, Audrey T. ;

Hall, Amanda L. ;

O'Brien, Lynne T. ;

Gehr-Swain, Beatrice N. ;

Wilkinson, Rosemary A. ;

Cox, Angie ;

Lewis, Sarah ;

Brown, Paul M. ;

Jhavar, Sameer G. ;

Tymrakiewicz, Malgorzata ;

Lophatananon, Artitaya ;

Bryant, Sarah L. ;

Horwich, Alan ;

Huddart, Robert A. ;

Khoo, Vincent S. ;

Parker, Christopher C. ;

Woodhouse, Christopher J. ;

Thompson, Alan ;

Christmas, Tim ;

Ogden, Chris ;

Fisher, Cyril ;

Jamieson, Charles ;

Cooper, Colin S. ;

English, Dallas R. ;

Hopper, John L. ;

Neal, David E. ;

Easton, Douglas F. .

NATURE GENETICS, 2008, 40 (03) :316-321

[4] Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men [J].

Freedman, Matthew L. ;

Haiman, Christopher A. ;

Patterson, Nick ;

McDonald, Gavin J. ;

Tandon, Arti ;

Waliszewska, Alicja ;

Penney, Kathryn ;

Steen, Robert G. ;

Ardlie, Kristin ;

John, Esther M. ;

Clakley-Girvan, Ingrid ;

Whitternore, Alice S. ;

Cooney, Kathleen A. ;

Ingles, Sue A. ;

Altshuler, David ;

Henderson, Brian E. ;

Reich, David .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (38) :14068-14073

[5] Multiple loci with different cancer specificities within the 8q24 gene desert [J].

Ghoussaini, Maya ;

Song, Honglin ;

Koessler, Thibaud ;

Al Olama, Ali Amin ;

Kote-Jarai, Zsofia ;

Driver, Kristy E. ;

Pooley, Karen A. ;

Ramus, Susan J. ;

Kjaer, Susanne Krueger ;

Hogdall, Estrid ;

DiCioccio, Richard A. ;

Whittemore, Alice S. ;

Gayther, Simon A. ;

Giles, Graham G. ;

Guy, Michelle ;

Edwards, Stephen M. ;

Morrison, Jonathan ;

Donovan, Jenny L. ;

Hamdy, Freddie C. ;

Dearnaley, David P. ;

Ardern-Jones, Audrey T. ;

Hall, Amanda L. ;

O'Brien, Lynne T. ;

Gehr-Swain, Beatrice N. ;

Wilkinson, Rosemary A. ;

Brown, Paul M. ;

Hopper, John L. ;

Neal, David E. ;

Pharoah, Paul D. P. ;

Ponder, Bruce A. J. ;

Eeles, Rosalind A. ;

Easton, Douglas F. ;

Dunning, Alison M. .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2008, 100 (13) :962-966

[6] Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24 [J].

Gudmundsson, Julius ;

Sulem, Patrick ;

Manolescu, Andrei ;

Amundadottir, Laufey T. ;

Gudbjartsson, Daniel ;

Helgason, Agnar ;

Rafnar, Thorunn ;

Bergthorsson, Jon T. ;

Agnarsson, Bjarni A. ;

Baker, Adam ;

Sigurdsson, Asgeir ;

Benediktsdottir, Kristrun R. ;

Jakobsdottir, Margret ;

Xu, Jianfeng ;

Blondal, Thorarinn ;

Kostic, Jelena ;

Sun, Jielin ;

Ghosh, Shyamali ;

Stacey, Simon N. ;

Mouy, Magali ;

Saemundsdottir, Jona ;

Backman, Valgerdur M. ;

Kristjansson, Kristleifur ;

Tres, Alejandro ;

Partin, Alan W. ;

Albers-Akkers, Marjo T. ;

Marcos, Javier Godino-Ivan ;

Walsh, Patrick C. ;

Swinkels, Dorine W. ;

Navarrete, Sebastian ;

Isaacs, Sarah D. ;

Aben, Katja K. ;

Graif, Theresa ;

Cashy, John ;

Ruiz-Echarri, Manuel ;

Wiley, Kathleen E. ;

Suarez, Brian K. ;

Witjes, J. Alfred ;

Frigge, Mike ;

Ober, Carole ;

Jonsson, Eirikur ;

Einarsson, Gudmundur V. ;

Mayordomo, Jose I. ;

Kiemeney, Lambertus A. ;

Isaacs, William B. ;

Catalona, William J. ;

Barkardottir, Rosa B. ;

Gulcher, Jeffrey R. ;

Thorsteinsdottir, Unnur ;

Kong, Augustine .

NATURE GENETICS, 2007, 39 (05) :631-637

[7] Multiple regions within 8q24 independently affect risk for prostate cancer [J].

Haiman, Christopher A. ;

Patterson, Nick ;

Freedman, Matthew L. ;

Myers, Simon R. ;

Pike, Malcolm C. ;

Waliszewska, Alicja ;

Neubauer, Julie ;

Tandon, Arti ;

Schirmer, Christine ;

McDonald, Gavin J. ;

Greenway, Steven C. ;

Stram, Daniel O. ;

Le Marchand, Loic ;

Kolonel, Laurence N. ;

Frasco, Melissa ;

Wong, David ;

Pooler, Loreall C. ;

Ardlie, Kristin ;

Oakley-Girvan, Ingrid ;

Whittemore, Alice S. ;

Cooney, Kathleen A. ;

John, Esther M. ;

Ingles, Sue A. ;

Altshuler, David ;

Henderson, Brian E. ;

Reich, David .

NATURE GENETICS, 2007, 39 (05) :638-644

[8] The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer [J].

Pomerantz, Mark M. ;

Ahmadiyeh, Nasim ;

Jia, Li ;

Herman, Paula ;

Verzi, Michael P. ;

Doddapaneni, Harshavardhan ;

Beckwith, Christine A. ;

Chan, Jennifer A. ;

Hills, Adam ;

Davis, Matt ;

Yao, Keluo ;

Kehoe, Sarah M. ;

Lenz, Heinz-Josef ;

Haiman, Christopher A. ;

Yan, Chunli ;

Henderson, Brian E. ;

Frenkel, Baruch ;

Barretina, Jordi ;

Bass, Adam ;

Tabernero, Josep ;

Baselga, Jose ;

Regan, Meredith M. ;

Manak, J. Robert ;

Shivdasani, Ramesh ;

Coetzee, Gerhard A. ;

Freedman, Matthew L. .

NATURE GENETICS, 2009, 41 (08) :882-884

[9] Evaluation of the 8q24 Prostate Cancer Risk Locus and MYC Expression [J].

Pomerantz, Mark M. ;

Beckwith, Christine A. ;

Regan, Meredith M. ;

Wyman, Stacia K. ;

Petrovics, Gyorgy ;

Chen, Yongmei ;

Hawksworth, Dorota J. ;

Schumacher, Fredrick R. ;

Mucci, Lorelei ;

Penney, Kathryn L. ;

Stampfer, Meir J. ;

Chan, Jennifer A. ;

Ardlie, Kristin G. ;

Fritz, Brian R. ;

Parkin, Rachael K. ;

Lin, Daniel W. ;

Dyke, Michelle ;

Herman, Paula ;

Lee, Steve ;

Oh, William K. ;

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