Inhibition of adhesion molecule expression by N-alkylthiopyridine-benzo[b]thiophene-2-carboxamides

被引：14

作者：

Boschelli, DH

Connor, DT

Lesch, ME

Schrier, DJ

机构：

[1] WARNER LAMBERT PARKE DAVIS, PARKE DAVIS PHARMACEUT RES, DEPT MED CHEM, ANN ARBOR, MI 48105 USA

[2] WARNER LAMBERT PARKE DAVIS, PARKE DAVIS PHARMACEUT RES, DEPT IMMUNOPATHOL, ANN ARBOR, MI 48105 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1996年 / 4卷 / 04期

关键词：

D O I：

10.1016/0968-0896(96)00046-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The surface levels of ICAM-1 and E-selectin on activated endothelial cells can be reduced by 3-alkoxybenzo[b]thio-phene-2-carboxamides. This property is shared by several N-alkylthiopyridine substituted imides. Combining structural elements of these two diverse series lead to a new class of small molecule inhibitors of adhesion molecule expression. Copyright (C) 1996 Elsevier Science Ltd

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收藏

页码：557 / 562

页数：6

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