Decarbonylative cross-coupling of cyclic anhydrides:: Introducing stereochemistry at an sp3 carbon in the cross-coupling event

被引：99

作者：

O'Brien, EM ^{[1
]}

Bercot, EA ^{[1
]}

Rovis, T ^{[1
]}

机构：

[1] Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 35期

关键词：

D O I：

10.1021/ja036290b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Treatment of cyclic anhydrides with stoichiometric amounts of nickel-neocuproine complex generates alkylcarboxylato-nickelalactones upon extrusion of CO. These metalacycles undergo cross-coupling with arylzinc reagents. The generated CO is sequestered in situ by a nickel-dppb complex. The overall sequence effects a secondary sp3(electrophile)-sp2(nucleophile) cross-coupling and allows for control of stereochemistry during the bond-forming event. Copyright © 2003 American Chemical Society.

引用

页码：10498 / 10499

页数：2

共 37 条

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