Vitamin D Deficiency Is Associated with Depletion of Circulating Endothelial Progenitor Cells and Endothelial Dysfunction in Patients with Type 2 Diabetes

被引:108
作者
Yiu, Yuen-Fung [1 ]
Chan, Yap-Hang [2 ]
Yiu, Kai-Hang [1 ]
Siu, Chung-Wah [1 ,3 ]
Li, Sheung-Wai
Wong, Lai-Yung [1 ]
Lee, Stephen W. L. [1 ,5 ]
Tam, Sidney [6 ]
Wong, Eric W. K. [6 ]
Cheung, Bernard M. Y. [3 ,4 ]
Tse, Hung-Fat [1 ,3 ]
机构
[1] Univ Hong Kong, Li Ka Shing Fac Med, Div Cardiol, Dept Med, Hong Kong, Hong Kong, Peoples R China
[2] Univ Hong Kong, Li Ka Shing Fac Med, Sch Publ Hlth, Hong Kong, Hong Kong, Peoples R China
[3] Univ Hong Kong, Li Ka Shing Fac Med, Res Ctr Heart Brain Hormone & Healthy Aging, Hong Kong, Hong Kong, Peoples R China
[4] Univ Hong Kong, Li Ka Shing Fac Med, Dept Med, Div Clin Pharmacol, Hong Kong, Hong Kong, Peoples R China
[5] Tung Wah Hosp, Dept Med, Hong Kong, Hong Kong, Peoples R China
[6] Queen Mary Hosp, Dept Clin Biochem Unit, Hong Kong, Hong Kong, Peoples R China
关键词
CARDIOVASCULAR RISK; CALCITRIOL BLUNTS; MELLITUS; CHOLESTEROL; PREVALENCE; IMPROVES; STRESS; IMPACT; ARTERY;
D O I
10.1210/jc.2010-2212
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Context: Vitamin D (Vit-D) deficiency is associated with type 2 diabetes mellitus (DM) and endothelial dysfunction. The relationship of Vit-D deficiency with circulating endothelial progenitor cells and endothelial dysfunction in type 2 DM patients nonetheless remains unclear. Objective: We aimed to investigate the cross-sectional association of Vit-D status with brachial flow-mediated dilation (FMD) and circulating endothelial progenitor cell (EPC) numbers in type 2 DM patients. Design, Setting, and Participants: We conducted a cross-sectional study of 280 patients (59% male, aged 68 +/- 10 yr) with type 2 DM recruited in outpatient clinics during the winter period. Main Outcome Measure: We measured serum 25-hydroxyvitamin D [25(OH)D] by an ELISA kit, circulating CD34+/kinase insert domain-containing receptor (KDR)+ and CD133+/KDR+ EPCs by flow cytometry and brachial artery FMD by vascular ultrasound, respectively. Results: The mean serum 25(OH)D concentration was 25.00 +/- 9.17 ng/ml, and 34.3% of patients had Vit-D deficiency [25(OH)D < 20 ng/ml]. Serum 25(OH)D concentration had a significant correlation with hemoglobin A1c level [B = -0.018, 95% confidence interval (CI) -0.035 to -0.002, P = 0.032]. Patients with Vit-D deficiency status had significantly lower brachial FMD (mean difference -1.43%, 95% CI -2.31 to -0.55, P = 0.001) and CD133+/KDR+ EPC counts (mean difference -0.12%, 95% CI -0.21 to -0.019, P = 0.022) than those with sufficient Vit-D status after adjustment for age, sex, and cardiovascular risk factors, including hemoglobin A1c levels. Conclusions: Our results demonstrate that serum 25(OH)D status was significantly associated with brachial artery FMD and circulating CD133+/KDR+ EPCs. This suggests that Vit-D deficiency might contribute to depletion of EPCs and endothelial dysfunction in patients with type 2 DM. (J Clin Endocrinol Metab 96: E830-E835, 2011)
引用
收藏
页码:E830 / E835
页数:6
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