Homocysteine and folate metabolism in depression

被引：232

作者：

Bottiglieri, T ^{[1
]}

机构：

[1] Baylor Univ, Med Ctr, Inst Metab Dis, Dallas, TX 75226 USA

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2005年 / 29卷 / 07期

关键词：

depression; folate; homocysteine; methylation; vitamin B6; vitamin B12;

D O I：

10.1016/j.pnpbp.2005.06.021

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Homocysteine is a sensitive marker of folate and vitamin B12 deficiency. Numerous studies have confirmed the association between folate deficiency and depression. It is not completely understood whether homocysteine is solely a marker for folate deficiency or if it may play a more direct role in the expression of mood disorders. This review describes the biochemical, neurochemical and clinical correlations of folate deficiency and hyperhomocysteinemia in relation to depression. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：1103 / 1112

页数：10

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