Complement control protein factor H: The good, the bad, and the inadequate

被引：323

作者：

Ferreira, Viviana P. ^{[1
]}

Pangburn, Michael K. ^{[2
]}

Cortes, Claudio ^{[1
]}

机构：

[1] Univ Toledo, Dept Med Microbiol & Immunol, Coll Med, Toledo, OH 43614 USA

[2] Univ Texas Hlth Sci Ctr, Dept Biochem, Ctr Biomed Res, Tyler, TX 75708 USA

来源：

MOLECULAR IMMUNOLOGY | 2010年 / 47卷 / 13期

关键词：

Alternative pathway; Complement; Human; Factor H; HEMOLYTIC-UREMIC SYNDROME; TRANSLATIONAL MINIREVIEW SERIES; SHORT CONSENSUS REPEAT; PAROXYSMAL-NOCTURNAL HEMOGLOBINURIA; PNEUMOCOCCAL SURFACE PROTEIN; PIGMENT EPITHELIAL-CELLS; HEPARIN-BINDING DOMAIN; REGULATORS FACTOR-H; C-TERMINAL DOMAINS; INHIBITOR FACTOR-H;

D O I：

10.1016/j.molimm.2010.05.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The complement system is an essential component of the innate immune system that participates in elimination of pathogens and altered host cells and comprises an essential link between the innate and adaptive immune system. Soluble and membrane-bound complement regulators protect cells and tissues from unintended complement-mediated injury. Complement factor H is a soluble complement regulator essential for controlling the alternative pathway in blood and on cell surfaces. Normal recognition of self-cell markers (i.e. polyanions) and C3b/C3d fragments is necessary for factor H function. Inadequate recognition of host cell surfaces by factor H due to mutations and polymorphisms have been associated with complement-mediated tissue damage and disease. On the other hand, unwanted recognition of pathogens and altered self-cells (i.e. cancer) by factor H is used as an immune evasion strategy. This review will focus on the current knowledge related to these versatile recognition properties of factor H. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：2187 / 2197

页数：11

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