Thyroid hormones: igniting brown fat via the brain

被引:54
作者
Cannon, Barbara [1 ]
Nedergaard, Jan [1 ]
机构
[1] Stockholm Univ, Wenner Gren Inst, S-10691 Stockholm, Sweden
关键词
ADIPOSE-TISSUE; ADULT HUMANS;
D O I
10.1038/nm0910-965
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Thyroid hormones increase the energy metabolism of the body in a process called 'thyroid thermogenesis'. Its molecular mechanism, however, has been elusive. Recent findings in rats suggest that it is localized to brown adipose tissue—our one truly thermogenic organ—and is mediated via the brain (pages 1001–1008).
引用
收藏
页码:965 / 967
页数:4
相关论文
共 12 条
[1]   Brown adipose tissue: Function and physiological significance [J].
Cannon, B ;
Nedergaard, J .
PHYSIOLOGICAL REVIEWS, 2004, 84 (01) :277-359
[2]   Brown adipose tissue - More than an effector of thermogenesis? [J].
Cannon, B ;
Houstek, J ;
Nedergaard, J .
MOLECULAR MECHANISMS OF FEVER, 1998, 856 :171-187
[3]  
CANNON B, INT J OBES IN PRESS
[4]   Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese [J].
Enerback, S ;
Jacobsson, A ;
Simpson, EM ;
Guerra, C ;
Yamashita, H ;
Harper, ME ;
Kozak, LP .
NATURE, 1997, 387 (6628) :90-94
[5]   Novel neural pathways for metabolic effects of thyroid hormone [J].
Fliers, Eric ;
Klieverik, Lars P. ;
Kalsbeek, Andries .
TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2010, 21 (04) :230-236
[6]   The rise, fall, and resurrection of the ventromedial hypothalamus in the regulation of feeding behavior and body weight [J].
King, BA .
PHYSIOLOGY & BEHAVIOR, 2006, 87 (02) :221-244
[7]   Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance [J].
Lopez, Miguel ;
Varela, Luis ;
Vazquez, Maria J. ;
Rodriguez-Cuenca, Sergio ;
Gonzalez, Carmen R. ;
Velagapudi, Vidya R. ;
Morgan, Donald A. ;
Schoenmakers, Erik ;
Agassandian, Khristofor ;
Lage, Ricardo ;
Martinez de Morentin, Pablo Blanco ;
Tovar, Sulay ;
Nogueiras, Ruben ;
Carling, David ;
Lelliott, Christopher ;
Gallego, Rosalia ;
Oresic, Matej ;
Chatterjee, Krishna ;
Saha, Asish K. ;
Rahmouni, Kamal ;
Dieguez, Carlos ;
Vidal-Puig, Antonio .
NATURE MEDICINE, 2010, 16 (09) :1001-U97
[8]   Unexpected evidence for active brown adipose tissue in adult humans [J].
Nedergaard, Jan ;
Bengtsson, Tore ;
Cannon, Barbara .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2007, 293 (02) :E444-E452
[9]   High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans Effects of Cold Exposure and Adiposity [J].
Saito, Masayuki ;
Okamatsu-Ogura, Yuko ;
Matsushita, Mami ;
Watanabe, Kumiko ;
Yoneshiro, Takeshi ;
Nio-Kobayashi, Junko ;
Iwanaga, Toshihiko ;
Miyagawa, Masao ;
Kameya, Toshimitsu ;
Nakada, Kunihiro ;
Kawai, Yuko ;
Tsujisaki, Masayuki .
DIABETES, 2009, 58 (07) :1526-1531
[10]   Thermogenic mechanisms and their hormonal regulation [J].
Silva, JE .
PHYSIOLOGICAL REVIEWS, 2006, 86 (02) :435-464