Chemical modulators of autophagy as biological probes and potential therapeutics

被引：230

作者：

Fleming, Angeleen ^{[1
,2
]}

Noda, Takeshi ^{[3
,4
]}

Yoshimori, Tamotsu ^{[3
,4
]}

Rubinsztein, David C. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Med Genet, Cambridge Inst Med Res, Cambridge, England

[2] Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge, England

[3] Osaka Univ, Dept Genet, Grad Sch Med, Osaka, Japan

[4] Osaka Univ, Grad Sch Frontier Biosci, Lab Intracellular Membrane Dynam, Osaka, Japan

来源：

NATURE CHEMICAL BIOLOGY | 2011年 / 7卷 / 01期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

ACTIVATED PROTEIN-KINASE; POLYGLUTAMINE EXPANSIONS; HUNTINGTONS-DISEASE; MEDIATED CLEAVAGE; HUMAN ATG4B; CELL-DEATH; LIFE-SPAN; COMPLEX; INHIBITORS; TREHALOSE;

D O I：

10.1038/NCHEMBIO.500

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Autophagy is an evolutionarily conserved mechanism for protein degradation that is critical for the maintenance of homeostasis in man. Autophagy has unexpected pleiotropic functions that favor survival of the cell, including nutrient supply under starvation, cleaning of the cellular interior, defense against infection and antigen presentation. Moreover, defective autophagy is associated with a diverse range of disease states, including neurodegeneration, cancer and Crohn's disease. Here we discuss the roles of mammalian autophagy in health and disease and highlight recent advances in pharmacological manipulation of autophagic pathways as a therapeutic strategy for a variety of pathological conditions.

引用

页码：9 / 17

页数：9

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