In vivo anti-inflammatory and in vitro antioxidant activities of Mediterranean dietary plants

被引：224

作者：

Conforti, Filomena ^{[1
]}

Sosa, Silvio ^{[2
]}

Marrelli, Mariangela ^{[1
]}

Menichini, Federica ^{[1
]}

Statti, Giancarlo A. ^{[1
]}

Uzunov, Dimitar ^{[3
]}

Tubaro, Aurelia ^{[2
]}

Menichini, Francesco ^{[1
]}

Della Loggia, Roberto ^{[2
]}

机构：

[1] Univ Calabria, Dept Pharmaceut Sci, I-87030 Commenda Di Rende, Italy

[2] Univ Trieste, Dept Mat & Nat Resources, I-34127 Trieste, Italy

[3] Univ Calabria, Natl Hist Museum Calabria & Botan Garden, I-87030 Commenda Di Rende, Italy

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2008年 / 116卷 / 01期

关键词：

anti-inflammatory activity; antioxidant activity; flavonoid content; phenolic content; radical scavenging activity; sterols composition;

D O I：

10.1016/j.jep.2007.11.015

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Five hydroalcoholic extracts of edible plants from Calabria region (Italy) used in local traditional medicine for the treatment of inflammatory diseases were evaluated for their in vivo topical anti-inflammatory activity (inhibition of croton oil-induced ear oedema in mice) and in vitro antioxidant and antiradical properties (inhibition of linoleic acid oxidation and bovine brain liposomes peroxidation, DPPH radical scavenging). All the extracts showed an anti-inflammatory effect: 300 mu g/cm(2) provoked oedema reductions ranging from 21 to 27%. All the extracts exerted also radical scavenging and/or antioxidant properties, the most active plant being Mentha aquatica L. (Lamiaceae) which contained the highest amount of phenolics (337 mg/g) and of flavonoids (15.75 mg/g). Moreover, the content and the composition of sterols were assessed by GC-MS in the examined plants Borago officinalis L. (Boraginaceac) contained the highest number of sterols. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：144 / 151

页数：8

共 51 条

[1] Free radicals, oxidative stress, and antioxidants in human health and disease [J].