Death by deamination: A novel host restriction system for HIV-1

被引：55

作者：

Goff, SP ^{[1
]}

机构：

[1] Columbia Univ Coll Phys & Surg, Howard Hughes Med Inst, Dept Biochem & Mol Biophys, New York, NY 10032 USA

来源：

CELL | 2003年 / 114卷 / 03期

关键词：

D O I：

10.1016/S0092-8674(03)00602-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A human gene with potent antiretroviral activity has recently been found to encode a new member of the family of cytidine deaminases, previously known to be involved in mRNA editing, immunoglobulin gene class switching, and immunoglobulin gene hypermutation. The enzyme attacks viral DNA as it is synthesized in infected cells and prevents the formation of functional proviruses. The Vif gene of HIV-1 blocks this host restriction and so allows virus replication.

引用

页码：281 / 283

页数：3

共 20 条

[1] Human immunodeficiency virus type 1 Vif does not influence expression or virion incorporation of gag-, pol-, and env-encoded proteins
Fouchier, RAM
Simon, JHM
Jaffe, AB
Malim, MH
[J]. JOURNAL OF VIROLOGY, 1996, 70 (12) : 8263 - 8269
[2] Inhibition of retroviral RNA production by ZAP, a CCCH-type zinc finger protein
Gao, GX
Guo, XM
Goff, SP
[J]. SCIENCE, 2002, 297 (5587) : 1703 - 1706
[3] DNA determination mediates innate immunity to retroviral infection
Harris, RS
Bishop, KN
Sheehy, AM
Craig, HM
Petersen-Mahrt, SK
Watt, IN
Neuberger, MS
Malim, MH
[J]. CELL, 2003, 113 (06) : 803 - 809
[4] RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators
Harris, RS
Petersen-Mahrt, SK
Neuberger, MS
[J]. MOLECULAR CELL, 2002, 10 (05) : 1247 - 1253
[5] Restriction of multiple divergent retroviruses by Lv1 and Ref1
Hatziioannou, T
Cowan, S
Goff, SP
Bieniasz, PD
Towers, GJ
[J]. EMBO JOURNAL, 2003, 22 (03) : 385 - 394
[6] Incorporation of uracil into minus strand DNA affects the specificity of plus strand synthesis initiation during lentiviral reverse transcription
Klarmann, GJ
Chen, X
North, TW
Preston, BD
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (10) : 7902 - 7909
[7] Hypermutation of HIV-1 DNA in the absence of the Vif protein
Lecossier, D
Bouchonnet, F
Clavel, F
Hance, AJ
[J]. SCIENCE, 2003, 300 (5622) : 1112 - 1112
[8] An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the viral Vif protein
Madani, N
Kabat, D
[J]. JOURNAL OF VIROLOGY, 1998, 72 (12) : 10251 - 10255
[9] Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts
Mangeat, B
Turelli, P
Caron, G
Friedli, M
Perrin, L
Trono, D
[J]. NATURE, 2003, 424 (6944) : 99 - 103
[10] Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif
Mariani, R
Chen, D
Schröfelbauer, B
Navarro, F
König, R
Bollman, B
Münk, C
Nymark-McMahon, H
Landau, NR
[J]. CELL, 2003, 114 (01) : 21 - 31

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