Comparison and combination of spectroscopic techniques for the detection of counterfeit medicines

被引：114

作者：

Sacre, Pierre-Yves ^{[1
,3
]}

Deconinck, Eric ^{[1
]}

De Beer, Thomas ^{[2
]}

Courselle, Patricia ^{[1
]}

Vancauwenberghe, Roy ^{[4
]}

Chiap, Patrice ^{[3
]}

Crommen, Jacques ^{[3
]}

De Beer, Jacques O. ^{[1
]}

机构：

[1] Sci Inst Publ Hlth, Lab Drug Anal, B-1050 Brussels, Belgium

[2] Univ Ghent, Lab Pharmaceut Proc Analyt Technol, B-9000 Ghent, Belgium

[3] Univ Liege, Dept Pharmaceut Analyt Chem, Inst Pharm, Liege, Belgium

[4] Fed Agcy Med & Hlth Prod, Brussels, Belgium

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2010年 / 53卷 / 03期

关键词：

Counterfeiting; Phosphodiesterase type 5 inhibitors; IR spectroscopy; Partial least squares; Raman spectroscopy; NEAR-INFRARED SPECTROSCOPY; RAMAN-SPECTROSCOPY; CITRATE VIAGRA; SILDENAFIL; TADALAFIL; IDENTIFICATION; CHEMOMETRICS; INTERNET; DRUGS; BASE;

D O I：

10.1016/j.jpba.2010.05.012

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

During this study, Fourier transform infrared spectroscopy (FT-IR), near infrared spectroscopy (NIR) and Raman spectroscopy were applied to 55 samples of counterfeit and imitations of Viagra (R) and 39 samples of counterfeit and imitations of Cialis (R). The aim of the study was to investigate which of these techniques and associations of them were the best for discriminating genuine from counterfeit and imitation samples Only the regions between 1800-400 cm(-1) and 7000-4000 cm(-1) were used for FT-IR and NIR spectroscopy respectively. Partial least square analysis has been used to allow the detection of counterfeit and imitation tablets It is shown that for the Viagra (R) samples, the best results were provided by a combination of FT-IR and NIR spectroscopy On the other hand, the best results for the Cialis (R) samples were provided by the combination of NIR and Raman spectroscopy (1400-1190 cm(-1)) These techniques not only permitted a clear discrimination between genuine and counterfeit or imitation samples but also the distinction of clusters among illegal samples. This might be interesting for forensic investigations by authorities (c) 2010 Elsevier B V All rights reserved

引用

页码：445 / 453

页数：9

共 29 条

[1] Determination of tadalafil in pharmaceutical preparation by HPLC using monolithic silica column
Aboul-Enein, HY
Ali, I
[J]. TALANTA, 2005, 65 (01) : 276 - 280
[2] Amin AS, 2009, J AOAC INT, V92, P125
[3] [Anonymous], [No title captured]
[4] Application of LC-ESI-MS-MS for detection of synthetic adulterants in herbal remedies
Bogusz, MJ
Hassan, H
Ai-Enazi, E
Ibrahim, Z
Al-Tufail, M
[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2006, 41 (02) : 554 - 564
[5] Construction of a universal model for non-invasive identification of cephalosporins for injection using near-infrared diffuse reflectance spectroscopy
Chong, Xiao-Meng
Hu, Chang-Qin
Feng, Yan-Chun
Pang, Huan-Huan
[J]. VIBRATIONAL SPECTROSCOPY, 2009, 49 (02) : 196 - 203
[6] Detection of Lipitor® counterfeits:: A comparison of NIR and Raman spectroscopy in combination with chemometrics
de Peinder, P.
Vredenbregt, M. J.
Visser, T.
de Kaste, D.
[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2008, 47 (4-5) : 688 - 694
[7] Detection of counterfeit Viagra® with Raman spectroscopy
de Veij, Marleen
Deneckere, Annelien
Vandenabeele, Peter
de Kaste, Dries
Moens, Luc
[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2008, 46 (02) : 303 - 309
[8] SIMPLS - AN ALTERNATIVE APPROACH TO PARTIAL LEAST-SQUARES REGRESSION
DEJONG, S
[J]. CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS, 1993, 18 (03) : 251 - 263
[9] Determination of the composition of counterfeit Heptodin™ tablets by near infrared chemical imaging and classical least squares estimation
Lopes, Marta B.
Wolff, Jean-Claude
Bioucas-Dias, Jose M.
Figueiredo, Mario A. T.
[J]. ANALYTICA CHIMICA ACTA, 2009, 641 (1-2) : 46 - 51
[10] Investigation into classification/sourcing of suspect counterfeit Heptodin™ tablets by near infrared chemical imaging
Lopes, Marta B.
Wolff, Jean-Claude
[J]. ANALYTICA CHIMICA ACTA, 2009, 633 (01) : 149 - 155

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