An artificial intelligence tool for bioprocess monitoring:: application to continuous production of gluconic acid by immobilized Aspergillus niger

被引：8

作者：

Sankpal, NV ^{[1
]}

Cheema, JJS ^{[1
]}

Tambe, SS ^{[1
]}

Kulkarni, BD ^{[1
]}

机构：

[1] Natl Chem Lab, Div Chem Engn, Pune 411008, Maharashtra, India

来源：

BIOTECHNOLOGY LETTERS | 2001年 / 23卷 / 11期

关键词：

artificial intelligence; Aspergillus niger; continuous fermentation; gluconic acid; immobilization; monitoring; symbolic regression;

D O I：

10.1023/A:1010551719536

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Experimental data on continuous fermentation of sucrose and glucose solution at low pH to gluconic acid by Asprgillus niger immobilized on cellulose fabric show complex dynamic behaviour including a decline in yield. The data have been analyzed using an artificial intelligence based symbolic regression technique to provide a mathematical model for predicting values of conversion 5, 10 and 15 h ahead values of conversion. These predictions can be used during continuous operations to monitor the bioprocess and adjust the residence time of fermentation to get complete and more efficient conversion of sucrose or glucose to gluconic acid.

引用

页码：911 / 916

页数：6

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