A precision technology for controlling protein adsorption and cell adhesion in bioMEMS

被引：5

作者：

Pan, YV ^{[1
]}

Hanein, Y ^{[1
]}

Leach-Scampavia, D ^{[1
]}

Böhringer, KF ^{[1
]}

Ratner, BD ^{[1
]}

Denton, DD ^{[1
]}

机构：

[1] Univ Washington, Seattle, WA 98195 USA

来源：

14TH IEEE INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS, TECHNICAL DIGEST | 2001年

关键词：

D O I：

10.1109/MEMSYS.2001.906571

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

A surface coating technique is investigated to enhance device biocompatibility by eliminating bio-fouling, the strong but nonspecific affinity of proteins and cells to attach to surfaces. This coating is a conformal, thin poly(ethylene glycol)-like film deposited in a glow discharge of tetraglyme. Substrates with different chemistries are successfully modified, and exhibit ultralow protein adsorption and cell attachment with the coating. This "stealth" or "non-fouling" coating can also be faithfully patterned using standard photolithography processes. The interaction of proteins and cells with patterned surfaces is limited only to the protein-adhesive domains, thus creating heterogeneous patterns of proteins and cell, cultures on the surface. The potential benefits of our technique to applications such as cell-based assays and micro-electrodes are discussed.

引用

页码：435 / 438

页数：4

共 17 条

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